Tag | Content |
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CPLM ID | CPLM-002639 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Asialoglycoprotein receptor 2 |
Protein Synonyms/Alias | ASGP-R 2; ASGPR 2; Hepatic lectin R2/3; HL-2; rHL-2 |
Gene Name | Asgr2 |
Gene Synonyms/Alias | Asgr-2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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135 | EKKQKDIKADHSTLL | acetylation | [1] | 146 | STLLFHLKHFPLDLR | acetylation | [1] | 219 | EEQEFVVKHRGAFHI | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
Sequence Annotation | DOMAIN 169 295 C-type lectin. MOD_RES 13 13 Phosphoserine (By similarity). LIPID 54 54 S-palmitoyl cysteine. CARBOHYD 97 97 N-linked (GlcNAc...). CARBOHYD 119 119 N-linked (GlcNAc...). CARBOHYD 165 165 N-linked (GlcNAc...). DISULFID 170 181 By similarity. DISULFID 198 293 By similarity. DISULFID 271 285 By similarity. |
Keyword | Calcium; Complete proteome; Direct protein sequencing; Disulfide bond; Endocytosis; Glycoprotein; Lectin; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 301 AA |
Protein Sequence | MEKDFQDIQQ LDSEENDHQL IGDEEQGSHV QNLRTENPRW GGQPPSRPFP QRLCSKFRLS 60 LLALAFNILL LVVICVVSSQ SMQLQKEFWT LKETLSNFST TTLMEFKALD SHGGSRNDNL 120 TSWETILEKK QKDIKADHST LLFHLKHFPL DLRTLTCQLA FFLSNGTECC PVNWVEFGGS 180 CYWFSRDGLT WAEADQYCQM ENAHLLVINS REEQEFVVKH RGAFHIWIGL TDKDGSWKWV 240 DGTEYRSNFK NWAFTQPDNW QGHEEGGSED CAEILSDGLW NDNFCQQVNR WACERKRDIT 300 Y 301 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0030246; F:carbohydrate binding; IEA:InterPro. GO:0030282; P:bone mineralization; IEP:RGD. GO:0006897; P:endocytosis; IEA:UniProtKB-KW. GO:0009100; P:glycoprotein metabolic process; IEA:Compara. GO:0055088; P:lipid homeostasis; IEA:Compara. GO:0031647; P:regulation of protein stability; IEA:Compara. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |