UniProt Accession

 E7ER27_HUMAN; E7ER27; E7EUW6 

Genbank Protein ID

 AC010409; AC024564 

Genbank Nucleotide ID

  

Protein Name

 Peroxisomal multifunctional enzyme type 2 

Protein Synonyms/Alias

  

Gene Name

 HSD17B4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
46	NDLGGDFKGVGKGSL	acetylation	[1, 2]
46	NDLGGDFKGVGKGSL	ubiquitination	[3]
57	KGSLAADKVVEEIRR	acetylation	[1, 2]
81	DSVEEGEKVVKTALD	acetylation	[1]
81	DSVEEGEKVVKTALD	ubiquitination	[2]
139	RAAWEHMKKQKYGRI	acetylation	[2]
184	SLAIEGRKSNIHCNT	ubiquitination	[3]
275	AVKANWKKICDFENA	ubiquitination	[3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 500 AA 

Protein Sequence

Gene Ontology

 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0016491; F:oxidoreductase activity; IEA:InterPro.
 GO:0055114; P:oxidation-reduction process; IEA:GOC. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.