| Tag | Content |
|---|
| CPLM ID | CPLM-014479 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calcium-activated potassium channel subunit alpha-1 |
Protein Synonyms/Alias | BK channel; BKCA alpha; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo-alpha; Slo1; Slowpoke homolog; Slo homolog |
Gene Name | Kcnma1 |
Gene Synonyms/Alias | Kcnma |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 584 | FSMRSFIKIEEDTWQ | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). |
Sequence Annotation | DOMAIN 416 559 RCK N-terminal.
REGION 557 577 Segment S7.
REGION 614 634 Segment S8.
REGION 682 686 Heme-binding motif.
REGION 784 804 Segment S9.
REGION 1006 1026 Segment S10.
MOTIF 353 356 Selectivity for potassium.
MOTIF 977 999 Calcium bowl.
METAL 440 440 Magnesium (By similarity).
METAL 463 463 Magnesium (By similarity).
METAL 465 465 Magnesium (By similarity).
METAL 986 986 Calcium; via carbonyl oxygen (By
METAL 989 989 Calcium; via carbonyl oxygen (By
METAL 992 992 Calcium (By similarity).
METAL 994 994 Calcium (By similarity).
MOD_RES 712 712 Phosphoserine (By similarity).
MOD_RES 1062 1062 Phosphothreonine (By similarity). |
Keyword | Alternative splicing; Calcium; Cell membrane; Complete proteome; Endoplasmic reticulum; Ion channel; Ion transport; Magnesium; Membrane; Metal-binding; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1209 AA |
Protein Sequence | MANGGGGGGG GSSGSSGGGG GGGGGETALR MSSNIHANHL SLDASSSSSS SSSSSSSSSS 60
SVHEPKMDAL IIPVTMEVPC DSRGQRMWWA FLASSMVTFF GGLFIILLWR TLKYLWTVCC 120
HCGGKTKEAQ KINNGSSQAD GTLKPVDEKE EVVAAEVGWM TSVKDWAGVM ISAQTLTGRV 180
LVVLVFALSI GALVIYFIDS SNPIESCQNF YKDFTLQIDM AFNVFFLLYF GLRFIAANDK 240
LWFWLEVNSV VDFFTVPPVF VSVYLNRSWL GLRFLRALRL IQFSEILQFL NILKTSNSIK 300
LVNLLSIFIS TWLTAAGFIH LVENSGDPWE NFQNNQALTY WECVYLLMVT MSTVGYGDVY 360
AKTTLGRLFM VFFILGGLAM FASYVPEIIE LIGNRKKYGG SYSAVSGRKH IVVCGHITLE 420
SVSNFLKDFL HKDRDDVNVE IVFLHNISPN LELEALFKRH FTQVEFYQGS VLNPHDLARV 480
KIESADACLI LANKYCADPD AEDASNIMRV ISIKNYHPKI RIITQMLQYH NKAHLLNIPS 540
WNWKEGDDAI CLAELKLGFI AQSCLAQGLS TMLANLFSMR SFIKIEEDTW QKYYLEGVSN 600
EMYTEYLSSA FVGLSFPTVC ELCFVKLKLL MIAIEYKSAN RESRSRKRIL INPGNHLKIQ 660
EGTLGFFIAS DAKEVKRAFF YCKACHDDVT DPKRIKKCGC RRLEDEQPPT LSPKKKQRNG 720
GMRNSPNTSP KLMRHDPLLI PGNDQIDNMD SNVKKYDSTG MFHWCAPKEI EKVILTRSEA 780
AMTVLSGHVV VCIFGDVSSA LIGLRNLVMP LRASNFHYHE LKHIVFVGSI EYLKREWETL 840
HNFPKVSILP GTPLSRADLR AVNINLCDMC VILSANQNNI DDTSLQDKEC ILASLNIKSM 900
QFDDSIGVLQ ANSQGFTPPG MDRSSPDNSP VHGMLRQPSI TTGVNIPIIT ELAKPGKLPL 960
VSVNQEKNSG THILMITELV NDTNVQFLDQ DDDDDPDTEL YLTQPFACGT AFAVSVLDSL 1020
MSATYFNDNI LTLIRTLVTG GATPELEALI AEENALRGGY STPQTLANRD RCRVAQLALL 1080
DGPFADLGDG GCYGDLFCKA LKTYNMLCFG IYRLRDAHLS TPSQCTKRYV ITNPPYEFEL 1140
VPTDLIFCLM QFDHNAGQSR ASLSHSSHSS QSSSKKSSSV HSIPSTANRP NRPKSRESRD 1200
KQKKEMVYR 1209 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |