CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005179
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Receptor-type tyrosine-protein phosphatase gamma 
Protein Synonyms/Alias
 Protein-tyrosine phosphatase gamma; R-PTP-gamma 
Gene Name
 PTPRG 
Gene Synonyms/Alias
 PTPG 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
831DMEAIPVKQFVKHIGubiquitination[1]
835IPVKQFVKHIGELYSubiquitination[1]
902PLPGKDSKHSDYINAubiquitination[2, 3]
929IATQGPLKSTFEDFWubiquitination[1, 2]
1083MLQQIKDKSTVNVLGubiquitination[3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Possesses tyrosine phosphatase activity. 
Sequence Annotation
 DOMAIN 58 321 Alpha-carbonic anhydrase.
 DOMAIN 346 443 Fibronectin type-III.
 DOMAIN 848 1119 Tyrosine-protein phosphatase 1.
 DOMAIN 1150 1410 Tyrosine-protein phosphatase 2.
 REGION 1060 1066 Substrate binding (By similarity).
 ACT_SITE 1060 1060 Phosphocysteine intermediate (By
 BINDING 1028 1028 Substrate (By similarity).
 BINDING 1104 1104 Substrate (By similarity).
 MOD_RES 115 115 Phosphothreonine (By similarity).
 MOD_RES 1182 1182 Phosphoserine.
 CARBOHYD 109 109 N-linked (GlcNAc...) (Potential).
 CARBOHYD 113 113 N-linked (GlcNAc...).
 CARBOHYD 156 156 N-linked (GlcNAc...) (Potential).
 CARBOHYD 359 359 N-linked (GlcNAc...) (Potential).
 CARBOHYD 444 444 N-linked (GlcNAc...).
 CARBOHYD 619 619 N-linked (GlcNAc...) (Potential).
 CARBOHYD 631 631 N-linked (GlcNAc...) (Potential).
 CARBOHYD 722 722 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Glycoprotein; Hydrolase; Membrane; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1445 AA 
Protein Sequence
MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGALHE NRHGSAVQIR RRKASGDPYW 60
AYSGAYGPEH WVTSSVSCGG RHQSPIDILD QYARVGEEYQ ELQLDGFDNE SSNKTWMKNT 120
GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGHSNGSAG SEHSINGRRF PVEMQIFFYN 180
PDDFDSFQTA ISENRIIGAM AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFVLRD 240
LLPASLGSYY RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE 300
YLRNNFRPQQ RLHDRVVSKS AVRDSWNHDM TDFLENPLGT EASKVCSSPP IHMKVQPLNQ 360
TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKATI SHVSPDSLYL 420
FRVQAVCRND MRSDFSQTML FQANTTRIFQ GTRIVKTGVP TASPASSADM APISSGSSTW 480
TSSGIPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT 540
AASASKQAAR PVLATTEALA SPGPDGDSSP TKDGEGTEEG EKDEKSESED GEREHEEDGE 600
KDSEKKEKSG VTHAAEERNQ TEPSPTPSSP NRTAEGGHQT IPGHEQDHTA VPTDQTGGRR 660
DAGPGLDPDM VTSTQVPPTA TEEQYAGSDP KRPEMPSKKP MSRGDRFSED SRFITVNPAE 720
KNTSGMISRP APGRMEWIIP LIVVSALTFV CLILLIAVLV YWRGCNKIKS KGFPRRFREV 780
PSSGERGEKG SRKCFQTAHF YVEDSSSPRV VPNESIPIIP IPDDMEAIPV KQFVKHIGEL 840
YSNNQHGFSE DFEEVQRCTA DMNITAEHSN HPENKHKNRY INILAYDHSR VKLRPLPGKD 900
SKHSDYINAN YVDGYNKAKA YIATQGPLKS TFEDFWRMIW EQNTGIIVMI TNLVEKGRRK 960
CDQYWPTENS EEYGNIIVTL KSTKIHACYT VRRFSIRNTK VKKGQKGNPK GRQNERVVIQ 1020
YHYTQWPDMG VPEYALPVLT FVRRSSAARM PETGPVLVHC SAGVGRTGTY IVIDSMLQQI 1080
KDKSTVNVLG FLKHIRTQRN YLVQTEEQYI FIHDALLEAI LGKETEVSSN QLHSYVNSIL 1140
IPGVGGKTRL EKQFKLVTQC NAKYVECFSA QKECNKEKNR NSSVVPSERA RVGLAPLPGM 1200
KGTDYINASY IMGYYRSNEF IITQHPLPHT TKDFWRMIWD HNAQIIVMLP DNQSLAEDEF 1260
VYWPSREESM NCEAFTVTLI SKDRLCLSNE EQIIIHDFIL EATQDDYVLE VRHFQCPKWP 1320
NPDAPISSTF ELINVIKEEA LTRDGPTIVH DEYGAVSAGM LCALTTLSQQ LENENAVDVF 1380
QVAKMINLMR PGVFTDIEQY QFIYKAMLSL VSTKENGNGP MTVDKNGAVL IADESDPAES 1440
MESLV 1445 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; TAS:ProtInc.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:ProtInc. 
Interpro
 IPR001148; Carbonic_anhydrase_a.
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 
Pfam
 PF00194; Carb_anhydrase
 PF00041; fn3
 PF00102; Y_phosphatase 
SMART
 SM01057; Carb_anhydrase
 SM00060; FN3
 SM00194; PTPc 
PROSITE
 PS51144; ALPHA_CA_2
 PS50853; FN3
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 
PRINTS
 PR00700; PRTYPHPHTASE.