UniProt Accession

 TRXB1_YEAST; P29509; D6VSY3 

Genbank Protein ID

 U10274; U28372; X04273; AY557749; BK006938 

Genbank Nucleotide ID

 AAA64747.1; AAB64789.1; AAS56075.1; DAA12193.1 

Protein Name

 Thioredoxin reductase 1 

Protein Synonyms/Alias

  

Gene Name

 TRR1 

Gene Synonyms/Alias

 YDR353W; D9476.5 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
77	RMREQSTKFGTEIIT	ubiquitination	[1]
95	SKVDLSSKPFKLWTE	acetylation	[2]
179	FLTKYGSKVFMLVRK	ubiquitination	[1]
221	LEAKGDGKLLNALRI	acetylation	[2]
293	AGDVQDSKYRQAITS	acetylation	[2]
293	AGDVQDSKYRQAITS	ubiquitination	[1]
313	MAALDAEKYLTSLE*	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Acts on thioredoxins 1 and 2. 

Sequence Annotation

 NP_BIND 11 14 FAD.
 NP_BIND 40 41 FAD.
 NP_BIND 295 297 FAD.
 BINDING 45 45 FAD; via amide nitrogen.
 BINDING 54 54 FAD.
 BINDING 87 87 FAD; via amide nitrogen and carbonyl
 BINDING 145 145 FAD.
 BINDING 288 288 FAD.
 MOD_RES 303 303 Phosphoserine.
 DISULFID 142 145 Redox-active.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; FAD; Flavoprotein; NADP; Oxidoreductase; Phosphoprotein; Redox-active center; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 319 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
 GO:0008198; F:ferrous iron binding; IDA:SGD.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0004791; F:thioredoxin-disulfide reductase activity; IDA:SGD.
 GO:0045454; P:cell redox homeostasis; IDA:SGD.
 GO:0034599; P:cellular response to oxidative stress; IGI:SGD.
 GO:0019430; P:removal of superoxide radicals; IEA:InterPro. 

Interpro

 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR008255; Pyr_nucl-diS_OxRdtase_2_AS.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom.
 IPR000103; Pyridine_nuc-diS_OxRdtase_2.
 IPR005982; Thioredox_Rdtase. 

Pfam

 PF00070; Pyr_redox
 PF07992; Pyr_redox_2 

SMART

  

PROSITE

 PS00573; PYRIDINE_REDOX_2 

PRINTS

 PR00368; FADPNR.
 PR00469; PNDRDTASEII.