UniProt Accession

 VDAC2_HUMAN; P45880; Q5VWK1; Q5VWK3; Q6IB40; Q7L3J5; Q9BWK8; Q9Y5I6 

Genbank Protein ID

 L08666; L08666; L06328; AF152227; AF152220; AF152221; AF152222; AF152223; AF152224; AF152225; AF152226; CR456964; AL390034; AL392111; AL392111; AL390034; AL390034; AL392111; AL392111; AL390034; AL390034; AL392111; AL392111; AL390034; BC000165; BC012883; BC072407 

Genbank Nucleotide ID

 AAA60144.1; AAA60145.1; AAB59457.1; AAD40241.1; AAD40241.1; AAD40241.1; AAD40241.1; AAD40241.1; AAD40241.1; AAD40241.1; AAD40241.1; CAG33245.1; CAH73108.1; CAH73108.1; CAI40914.1; CAI40914.1; CAH73107.1; CAH73107.1; CAI40911.1; CAI40911.1; CAH73106.1; CAH73106.1; CAI40910.1; CAI40910.1; AAH00165.2; AAH12883.2; AAH72407.1 

Protein Name

 Voltage-dependent anion-selective channel protein 2 

Protein Synonyms/Alias

 VDAC-2; hVDAC2; Outer mitochondrial membrane protein porin 2 

Gene Name

 VDAC2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
46	AARDIFNKGFGFGLV	ubiquitination	[1, 2]
87	VTGTLETKYKWCEYG	ubiquitination	[2]
135	TFSPNTGKKSGKIKS	ubiquitination	[2]
136	FSPNTGKKSGKIKSS	ubiquitination	[1]
250	TRFGIAAKYQLDPTA	ubiquitination	[1, 2]
262	PTASISAKVNNSSLI	ubiquitination	[2]
300	SINAGGHKVGLALEL	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. 

Sequence Annotation

 NP_BIND 253 255 NAD (By similarity).
 NP_BIND 271 275 NAD (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 31 31 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane; NAD; Nucleotide-binding; Polymorphism; Porin; Reference proteome; Transmembrane; Transmembrane beta strand; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 294 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
 GO:0005741; C:mitochondrial outer membrane; TAS:ProtInc.
 GO:0046930; C:pore complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0015288; F:porin activity; IEA:UniProtKB-KW.
 GO:0008308; F:voltage-gated anion channel activity; TAS:UniProtKB.
 GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0032272; P:negative regulation of protein polymerization; IEA:Compara. 

Interpro

 IPR023614; Porin_dom.
 IPR001925; Porin_Euk.
 IPR027246; Porin_Euk/Tom40. 

Pfam

 PF01459; Porin_3 

SMART

  

PROSITE

 PS00558; EUKARYOTIC_PORIN 

PRINTS

 PR00185; EUKARYTPORIN.