CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044092
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Segment polarity protein dishevelled homolog DVL-2 
Protein Synonyms/Alias
  
Gene Name
 DVL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
277VLRDIVHKPGPIVLTubiquitination[1, 2, 3]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 291 AA 
Protein Sequence
MLRVVKEEIS DDNARLPCFN GRVVSWLVSS DNPQPEMAPP VHEPRAELAP PAPPLPPLPP 60
ERTSGIGDSR PPSFHPNVSS SHENLEPETE TESVVSLRRE RPRRRDSTGG HRTGGPSRLE 120
RHLAGYESSS TLMTSELEST SLGDSDEEDT MSRFSSSTEQ SSASRLLKRH RRRRKQRPPR 180
LERTSSFSSV TDSTMSLNII TVTLNMEKYN FLGISIVGQS NERGDGGIYI GSIMKGGAVA 240
ADGRIEPGDM LLQVNDMNFE NMSNDDAVRV LRDIVHKPGP IVLTVAKCWD P 291 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:GOC. 
Interpro
 IPR008341; Dishevelled_2.
 IPR003351; Dishevelled_protein_dom.
 IPR001158; DIX.
 IPR015506; Dsh/Dvl-rel.
 IPR001478; PDZ. 
Pfam
 PF02377; Dishevelled
 PF00778; DIX
 PF00595; PDZ 
SMART
 SM00228; PDZ 
PROSITE
 PS50841; DIX
 PS50106; PDZ 
PRINTS