| Tag | Content |
|---|
| CPLM ID | CPLM-016918 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein argonaute-3 |
Protein Synonyms/Alias | Argonaute3; mAgo3; Argonaute RISC catalytic component 3; Eukaryotic translation initiation factor 2C 3; eIF-2C 3; eIF2C 3; Piwi/argonaute family protein meIF2C3 |
Gene Name | Ago3 |
Gene Synonyms/Alias | Eif2c3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 480 | DQLRKISKDAGMPIQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. |
Sequence Annotation | DOMAIN 236 349 PAZ.
DOMAIN 518 819 Piwi. |
Keyword | Complete proteome; Cytoplasm; Reference proteome; Ribonucleoprotein; RNA-binding; RNA-mediated gene silencing; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 860 AA |
Protein Sequence | MEIGSAGPIG AQPLFIVPRR PGYGTMGKPI KLLANCFQVE IPKIDVYLYE VDIKPDKCPR 60
RVNREVVDSM VQHFKVTIFG DRRPVYDGKR SLYTANPLPV ATTGVDLDVT LPGEGGKDRP 120
FKVSVKFVSR VSWHLLHEAL AGGTLPEPLE LDKPVSTNPV HAVDVVLRHL PSMKYTPVGR 180
SFFSAPEGYD HPLGGGREVW FGFHQSVRPA MWKMMLNIDV SATAFYKAQP VIQFMCEVLD 240
IHNIDEQPRP LTDSHRVKFT KEIKGLKVEV THCGTMRRKY RVCNVTRRPA SHQTFPLQLE 300
NGQTVERTVA QYFREKYTLQ LKYPHLPCLQ VGQEQKHTYL PLEVCNIVAG QRCIKKLTDN 360
QTSTMIKATA RSAPDRQEEI SRLVRSANYE TDPFVQEFQF KVRDEMAHVT GRVLPAPMLQ 420
YGGRNRTVAT PSHGVWDMRG KQFHTGVEIK MWAIACFATQ RQCREEILKG FTDQLRKISK 480
DAGMPIQGQP CFCKYAQGAD SVEPMFRHLK NTYSGLQLII VILPGKTPVY AEVKRVGDTL 540
LGMATQCVQV KNVIKTSPQT LSNLCLKINV KLGGINNILV PHQRPSVFQQ PVIFLGADVT 600
HPPAGDGKKP SIAAVVGSMD AHPSRYCATV RVQRPRQEII QDLASMVREL LIQFYKSTRF 660
KPTRIIFYRD GVSEGQFRQV LYYELLAIRE ACISLEKDYQ PGITYIVVQK RHHTRLFCAD 720
RTERVGRSGN IPAGTTVDTD ITHPYEFDFY LCSHAGIQGT SRPSHYHVLW DDNFFTADEL 780
QLLTYQLCHT YVRCTRSVSI PAPAYYAHLV AFRARYHLVD KEHDSAEGSH VSGQSNGRDP 840
QALAKAVQIH QDTLRTMYFA 860 |
Gene Ontology | GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell. GO:0035068; C:micro-ribonucleoprotein complex; IDA:MGI. GO:0003723; F:RNA binding; IDA:MGI. GO:0006402; P:mRNA catabolic process; ISS:UniProtKB. GO:0035278; P:negative regulation of translation involved in gene silencing by miRNA; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |