CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045104
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Zinc transporter ZIP6 
Protein Synonyms/Alias
  
Gene Name
 SLC39A6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23DKKKKNQKKPENDDDubiquitination[1]
24KKKKNQKKPENDDDVubiquitination[1, 2, 3]
34NDDDVEIKKQLSKYEubiquitination[1, 2, 3, 4]
35DDDVEIKKQLSKYESubiquitination[1, 4]
39EIKKQLSKYESQLSTubiquitination[1, 2, 4]
50QLSTNEEKVDTDDRTubiquitination[1, 2, 4, 5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 273 AA 
Protein Sequence
MFLVEHVLTL IKQFKDKKKK NQKKPENDDD VEIKKQLSKY ESQLSTNEEK VDTDDRTEGY 60
LRADSQEPSH FDSQQPAVLE EEEVMIAHAH PQEVYNEYVP RGCKNKCHSH FHDTLGQSDD 120
LIHHHHDYHH ILHHHHHQNH HPHSHSQRYS REELKDAGVA TLAWMVIMGD GLHNFSDGLA 180
IGAAFTEGLS SGLSTSVAVF CHELPHELGD FAVLLKAGMT VKQAVLYNAL SAMLAYLGMA 240
TGIFIGHYAE NVSMWIFALT AGLFMYVALV DMV 273 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro. 
Interpro
 IPR003689; ZIP. 
Pfam
 PF02535; Zip 
SMART
  
PROSITE
  
PRINTS