| Tag | Content |
|---|
| CPLM ID | CPLM-010750 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | S-adenosylmethionine synthase isoform type-1 |
Protein Synonyms/Alias | AdoMet synthase 1; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III |
Gene Name | MAT1A |
Gene Synonyms/Alias | AMS1; MATA1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 223 | EEMRRALKEQVIRAV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. |
Sequence Annotation | NP_BIND 131 136 ATP (Potential).
METAL 31 31 Magnesium (By similarity).
METAL 57 57 Potassium (By similarity).
METAL 283 283 Potassium (By similarity).
METAL 291 291 Magnesium (By similarity).
BINDING 29 29 Substrate.
BINDING 159 159 ATP (Potential).
BINDING 179 179 Substrate.
BINDING 247 247 Substrate.
BINDING 249 249 Substrate; via carbonyl oxygen.
BINDING 258 258 Substrate.
MOD_RES 120 120 S-nitrosocysteine (By similarity).
DISULFID 34 60 By similarity. |
Keyword | 3D-structure; ATP-binding; Cobalt; Complete proteome; Disease mutation; Disulfide bond; Magnesium; Metal-binding; Nucleotide-binding; One-carbon metabolism; Polymorphism; Potassium; Reference proteome; S-nitrosylation; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 395 AA |
Protein Sequence | MNGPVDGLCD HSLSEGVFMF TSESVGEGHP DKICDQISDA VLDAHLKQDP NAKVACETVC 60
KTGMVLLCGE ITSMAMVDYQ RVVRDTIKHI GYDDSAKGFD FKTCNVLVAL EQQSPDIAQC 120
VHLDRNEEDV GAGDQGLMFG YATDETEECM PLTIILAHKL NARMADLRRS GLLPWLRPDS 180
KTQVTVQYMQ DNGAVIPVRI HTIVISVQHN EDITLEEMRR ALKEQVIRAV VPAKYLDEDT 240
VYHLQPSGRF VIGGPQGDAG VTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW 300
VAKSLVKAGL CRRVLVQVSY AIGVAEPLSI SIFTYGTSQK TERELLDVVH KNFDLRPGVI 360
VRDLDLKKPI YQKTACYGHF GRSEFPWEVP RKLVF 395 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004478; F:methionine adenosyltransferase activity; TAS:ProtInc. GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome. GO:0032259; P:methylation; TAS:Reactome. GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:UniProtKB-UniPathway. GO:0000096; P:sulfur amino acid metabolic process; TAS:Reactome. GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |