| Tag | Content |
|---|
| CPLM ID | CPLM-006611 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein UTH1 |
Protein Synonyms/Alias | Youth protein 1 |
Gene Name | UTH1 |
Gene Synonyms/Alias | YKR042W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 186 | SVGGLYCKNGKLYRS | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Involved in aging, oxidative stress response, and in the regulation of mitochondrial biogenesis. Inactivation of UTH1 increases life span, leads to higher resistance to heat stress and against hydrogen peroxide, and increases sensitivity to the superoxide radical-generating drug paraquat and to copper. Also required for the selective autophagic degradation of mitochondria (mitophagy) in response to nitrogen starvation. May play a role in cell wall morphogenesis and septation. |
Sequence Annotation | |
Keyword | Autophagy; Cell cycle; Cell division; Cell wall; Cell wall biogenesis/degradation; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome; Secreted; Septation; Signal; Stress response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 365 AA |
Protein Sequence | MKLSALLALS ASTAVLAAPA VHHSDNHHHN DKRAVVTVTQ YVNADGAVVI PAATTATSAA 60
ADGKVESVAA ATTTLSSTAA AATTSAAASS SSSSSSSSSS SSSVGSGDFE DGTISCSDFP 120
SGQGAVSLDW LGLGGWASIM DMNGNTATSC QDGYYCSYAC SPGYAKTQWP SEQPSDGRSV 180
GGLYCKNGKL YRSNTDTNSL CVEGQGSAQA VNKVSGSIAI CGTDYPGSEN MVVPTVVGAG 240
SSQPINVIKE DSYYQWQGKK TSAQYYVNNA GVSVEDGCIW GTEGSGVGNW APVVLGAGYT 300
DGITYLSIIP NPNNKEAPNF NIKIVATDGS TVNGACSYEN GVYSGSGSDG CTVSVTSGSA 360
NFVFY 365 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-KW. GO:0009277; C:fungal-type cell wall; IDA:SGD. GO:0005741; C:mitochondrial outer membrane; TAS:SGD. GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW. GO:0009272; P:fungal-type cell wall biogenesis; IMP:SGD. GO:0000422; P:mitochondrion degradation; IMP:SGD. GO:0001308; P:negative regulation of chromatin silencing involved in replicative cell aging; TAS:SGD. GO:0006950; P:response to stress; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |