CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022716
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase Sgk2 
Protein Synonyms/Alias
 Serum/glucocorticoid-regulated kinase 2 
Gene Name
 Sgk2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
271LLQGLLHKDQRQRLGubiquitination[1]
303NWDDLYHKRLTPPFNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. 
Sequence Annotation
 DOMAIN 35 292 Protein kinase.
 DOMAIN 293 367 AGC-kinase C-terminal.
 NP_BIND 41 49 ATP (By similarity).
 MOTIF 68 78 Nuclear localization signal (By
 ACT_SITE 159 159 Proton acceptor (By similarity).
 BINDING 64 64 ATP (By similarity).
 MOD_RES 193 193 Phosphothreonine; by PDPK1 (By
 MOD_RES 356 356 Phosphoserine (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 367 AA 
Protein Sequence
MASSPVGVPS PQPSRANGNI NLGPSANPNA RPTDFDFLKV IGKGNYGKVL LAKRKSDGAF 60
YAVKVLQKKS ILKNKEQNHI MAERNVLLKN VRHPFLVGLR YSFQTPEKLY FVLDYVNGGE 120
LFFHLQRERR FLEPRARFYT AEVASAIGYL HSLNIIYRDL KPENILLDCQ GHVVLTDFGL 180
CKECVEPEET TSTFCGTPEY LAPEVLRKEP YDRAVDWWCL GAVLYEMLHG LPPFFNTDVA 240
QMYENILHQP LQIPGGRTVA ACDLLQGLLH KDQRQRLGSK EDFLDIKNHM FFSPINWDDL 300
YHKRLTPPFN PNVEGPADLK HFDPEFTQEA VSKSIGCTPD TVASSSGASS AFLGFSYAQD 360
DDDILDS 367 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase
 PF00433; Pkinase_C 
SMART
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS