CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040484
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Akr1b10 
Protein Synonyms/Alias
  
Gene Name
 Akr1b10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
70FEKSLVKKAFQKTLLacetylation[1]
74LVKKAFQKTLLDLKLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 ACT_SITE 28 28 Proton donor (By similarity).  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 295 AA 
Protein Sequence
QSPPDKVKEA VKAAIDAGYR HFDCAYVYQN ESEVGEAIQE KIKEKAVRRE DLFIVSKLWP 60
TFFEKSLVKK AFQKTLLDLK LDYLDLYLIH WPQGFQSGNV FLPTDDKGNV LTSKYTFLDA 120
WEGMEELVDQ GLVKALGVSN FNHFQIERLL NKPGLKHKPV TNQVECHPYL TQEKLIQYCH 180
SKGIVVTAYS PLGSPDRPSA KPEDPVLLEI PKIKEIASKH KKTAAQVLIR FHIERNVAVI 240
PKSVTPSRIQ ENIQVFDFQL SEEDMAAILS FNRNWRACGL FAASRNEDFP FHSEY 295 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:RGD.
 GO:0070401; F:NADP+ binding; IDA:RGD.
 GO:0052650; F:NADP-retinol dehydrogenase activity; IDA:RGD.
 GO:0070402; F:NADPH binding; IDA:RGD.
 GO:0016918; F:retinal binding; IDA:RGD.
 GO:0019751; P:polyol metabolic process; IDA:RGD.
 GO:0042574; P:retinal metabolic process; IDA:RGD.
 GO:0042572; P:retinol metabolic process; IDA:RGD. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 
PRINTS
 PR00069; ALDKETRDTASE.