UniProt Accession

 ERG6_YEAST; P25087; D6VZG6 

Genbank Protein ID

 X74249; S72460; Z49810; X53830; BK006946 

Genbank Nucleotide ID

 CAA52308.1; AAB31378.1; CAA89944.1; CAA37826.1; DAA09890.1 

Protein Name

 Sterol 24-C-methyltransferase 

Protein Synonyms/Alias

 Delta(24)-sterol C-methyltransferase 

Gene Name

 ERG6 

Gene Synonyms/Alias

 ISE1; LIS1; SED6; YML008C; YM9571.10C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
34	GLSALMSKNNSAQKE	ubiquitination	[1]
45	AQKEAVQKYLRNWDG	acetylation	[2]
96	FHFSRFYKGESFAAS	ubiquitination	[1]
114	HEHYLAYKAGIQRGD	acetylation	[2]
114	HEHYLAYKAGIQRGD	ubiquitination	[1]
157	NNDYQIAKAKYYAKK	ubiquitination	[1]
175	SDQMDFVKGDFMKMD	acetylation	[2]
190	FEENTFDKVYAIEAT	ubiquitination	[1]
202	EATCHAPKLEGVYSE	acetylation	[2]
240	ENNPEHRKIAYEIEL	ubiquitination	[1]
335	GLAPEGSKEVTAALE	ubiquitination	[1]
355	LVAGGKSKLFTPMML	ubiquitination	[1]
367	MMLFVARKPENAETP	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 99 99 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Lipid biosynthesis; Lipid metabolism; Methyltransferase; Phosphoprotein; Reference proteome; S-adenosyl-L-methionine; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 383 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0005811; C:lipid particle; IDA:SGD.
 GO:0005741; C:mitochondrial outer membrane; IDA:SGD.
 GO:0003838; F:sterol 24-C-methyltransferase activity; IDA:SGD.
 GO:0006696; P:ergosterol biosynthetic process; IMP:SGD. 

Interpro

 IPR025810; ERG6.
 IPR013216; Methyltransf_11.
 IPR013705; Sterol_MeTrfase_C. 

Pfam

 PF08241; Methyltransf_11
 PF08498; Sterol_MT_C 

SMART

  

PROSITE

  

PRINTS