CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006552
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aryl hydrocarbon receptor 
Protein Synonyms/Alias
 Ah receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76 
Gene Name
 AHR 
Gene Synonyms/Alias
 BHLHE76 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
24KPVQKTVKPIPAEGIubiquitination[1]
32PIPAEGIKSNPSKRHubiquitination[1, 2]
63FPQDVINKLDKLSVLubiquitination[1, 2, 3]
88SFFDVALKSSPTERNubiquitination[1, 2, 3, 4]
372SNARLLYKNGRPDYIubiquitination[2, 3]
438TKNGTSGKDSATTSTubiquitination[1]
510MGNDTILKHEQIDQPubiquitination[1]
535PGLFQDSKNSDLYSIubiquitination[1, 2, 3]
544SDLYSIMKNLGIDFEubiquitination[3, 4]
560IRHMQNEKFFRNDFSubiquitination[1, 2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
 Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. 
Sequence Annotation
 DOMAIN 27 80 bHLH.
 DOMAIN 111 181 PAS 1.
 DOMAIN 275 342 PAS 2.
 DOMAIN 348 386 PAC.  
Keyword
 Activator; Cell cycle; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Polymorphism; Receptor; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 848 AA 
Protein Sequence
MNSSSANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL ASLLPFPQDV 60
INKLDKLSVL RLSVSYLRAK SFFDVALKSS PTERNGGQDN CRAANFREGL NLQEGEFLLQ 120
ALNGFVLVVT TDALVFYASS TIQDYLGFQQ SDVIHQSVYE LIHTEDRAEF QRQLHWALNP 180
SQCTESGQGI EEATGLPQTV VCYNPDQIPP ENSPLMERCF ICRLRCLLDN SSGFLAMNFQ 240
GKLKYLHGQK KKGKDGSILP PQLALFAIAT PLQPPSILEI RTKNFIFRTK HKLDFTPIGC 300
DAKGRIVLGY TEAELCTRGS GYQFIHAADM LYCAESHIRM IKTGESGMIV FRLLTKNNRW 360
TWVQSNARLL YKNGRPDYII VTQRPLTDEE GTEHLRKRNT KLPFMFTTGE AVLYEATNPF 420
PAIMDPLPLR TKNGTSGKDS ATTSTLSKDS LNPSSLLAAM MQQDESIYLY PASSTSSTAP 480
FENNFFNESM NECRNWQDNT APMGNDTILK HEQIDQPQDV NSFAGGHPGL FQDSKNSDLY 540
SIMKNLGIDF EDIRHMQNEK FFRNDFSGEV DFRDIDLTDE ILTYVQDSLS KSPFIPSDYQ 600
QQQSLALNSS CMVQEHLHLE QQQQHHQKQV VVEPQQQLCQ KMKHMQVNGM FENWNSNQFV 660
PFNCPQQDPQ QYNVFTDLHG ISQEFPYKSE MDSMPYTQNF ISCNQPVLPQ HSKCTELDYP 720
MGSFEPSPYP TTSSLEDFVT CLQLPENQKH GLNPQSAIIT PQTCYAGAVS MYQCQPEPQH 780
THVGQMQYNP VLPGQQAFLN KFQNGVLNET YPAELNNINN TQTTTHLQPL HHPSEARPFP 840
DLTSSGFL 848 
Gene Ontology
 GO:0034752; C:cytosolic aryl hydrocarbon receptor complex; TAS:DFLAT.
 GO:0005667; C:transcription factor complex; TAS:DFLAT.
 GO:0051879; F:Hsp90 protein binding; IDA:BHF-UCL.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:UniProtKB.
 GO:0046982; F:protein heterodimerization activity; TAS:DFLAT.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:DFLAT.
 GO:0006915; P:apoptotic process; TAS:UniProtKB.
 GO:0001568; P:blood vessel development; NAS:DFLAT.
 GO:0007049; P:cell cycle; TAS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045899; P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; IEA:Compara.
 GO:0030850; P:prostate gland development; IEA:Compara.
 GO:0030888; P:regulation of B cell proliferation; IDA:DFLAT.
 GO:0006950; P:response to stress; IDA:UniProtKB.
 GO:0006805; P:xenobiotic metabolic process; TAS:DFLAT. 
Interpro
 IPR011598; bHLH_dom.
 IPR001610; PAC.
 IPR000014; PAS.
 IPR013767; PAS_fold.
 IPR013655; PAS_fold_3. 
Pfam
 PF00010; HLH
 PF00989; PAS
 PF08447; PAS_3 
SMART
 SM00353; HLH
 SM00086; PAC
 SM00091; PAS 
PROSITE
 PS50888; BHLH
 PS50113; PAC
 PS50112; PAS 
PRINTS