UniProt Accession

 MYG_MOUSE; P04247 

Genbank Protein ID

 BC025172; X04405; X04417 

Genbank Nucleotide ID

 AAH25172.1; CAA27994.1; CAA27994.1 

Protein Name

 Myoglobin 

Protein Synonyms/Alias

  

Gene Name

 Mb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
43	THPETLDKFDKFKNL	acetylation	[1, 2]
43	THPETLDKFDKFKNL	ubiquitination	[3]
46	ETLDKFDKFKNLKSE	acetylation	[1]
46	ETLDKFDKFKNLKSE	ubiquitination	[3]
51	FDKFKNLKSEEDMKG	ubiquitination	[3]
57	LKSEEDMKGSEDLKK	ubiquitination	[3]
63	MKGSEDLKKHGCTVL	ubiquitination	[3]
78	TALGTILKKKGQHAA	acetylation	[1]
79	ALGTILKKKGQHAAE	ubiquitination	[3]
80	LGTILKKKGQHAAEI	ubiquitination	[3]
97	LAQSHATKHKIPVKY	ubiquitination	[3]
118	IIIEVLKKRHSGDFG	ubiquitination	[3]
134	DAQGAMSKALELFRN	acetylation	[1]
134	DAQGAMSKALELFRN	ubiquitination	[3]
146	FRNDIAAKYKELGFQ	acetylation	[1]
146	FRNDIAAKYKELGFQ	ubiquitination	[3]
148	NDIAAKYKELGFQG*	acetylation	[1]

Reference

 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. 

Sequence Annotation

 METAL 65 65 Iron (heme distal ligand).
 METAL 94 94 Iron (heme proximal ligand).  

Keyword

 Complete proteome; Direct protein sequencing; Heme; Iron; Metal-binding; Muscle protein; Oxygen transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 154 AA 

Protein Sequence

Gene Ontology

 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0019825; F:oxygen binding; IEA:Compara.
 GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW.
 GO:0050873; P:brown fat cell differentiation; IDA:MGI.
 GO:0043353; P:enucleate erythrocyte differentiation; IMP:MGI.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0009725; P:response to hormone stimulus; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0001666; P:response to hypoxia; IMP:MGI.
 GO:0031444; P:slow-twitch skeletal muscle fiber contraction; IEA:Compara. 

Interpro

 IPR000971; Globin.
 IPR009050; Globin-like.
 IPR012292; Globin_dom.
 IPR002335; Myoglobin. 

Pfam

 PF00042; Globin 

SMART

  

PROSITE

 PS01033; GLOBIN 

PRINTS

 PR00613; MYOGLOBIN.