UniProt Accession

 NDUV1_MOUSE; Q91YT0 

Genbank Protein ID

 AK075692; BC014818; BC041682 

Genbank Nucleotide ID

 BAC35893.1; AAH14818.1; AAH41682.1 

Protein Name

 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 

Protein Synonyms/Alias

 Complex I-51kD; CI-51kD; NADH-ubiquinone oxidoreductase 51 kDa subunit 

Gene Name

 Ndufv1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
36	KTSFGSLKDEDRIFT	acetylation	[1]
64	LRRGDWYKTKEILLK	acetylation	[1]
66	RGDWYKTKEILLKGP	acetylation	[1]
81	DWILGEMKTSGLRGR	acetylation	[1, 2]
104	LKWSFMNKPSDGRPK	acetylation	[1, 2]
365	DRSTDIVKAIARLIE	acetylation	[1]
375	ARLIEFYKHESCGQC	acetylation	[1, 2]
394	EGVDWMNKVMARFVK	acetylation	[1]
401	KVMARFVKGDARPAE	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647] 

Functional Description

 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). 

Sequence Annotation

 NP_BIND 87 96 NAD(H) (By similarity).
 NP_BIND 199 247 FMN (By similarity).
 METAL 379 379 Iron-sulfur (4Fe-4S) (Potential).
 METAL 382 382 Iron-sulfur (4Fe-4S) (Potential).
 METAL 385 385 Iron-sulfur (4Fe-4S) (Potential).
 METAL 425 425 Iron-sulfur (4Fe-4S) (Potential).
 MOD_RES 81 81 N6-acetyllysine.
 MOD_RES 104 104 N6-acetyllysine.
 MOD_RES 375 375 N6-acetyllysine.  

Keyword

 4Fe-4S; Acetylation; Complete proteome; Direct protein sequencing; Electron transport; Flavoprotein; FMN; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Reference proteome; Respiratory chain; Transit peptide; Transport; Ubiquinone. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 464 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Compara.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0010181; F:FMN binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 

Interpro

 IPR001949; NADH-UbQ_OxRdtase_51kDa_CS.
 IPR019575; NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
 IPR011537; NADH-UbQ_OxRdtase_suF.
 IPR011538; NADH_UbQ_OxRdtase_51kDa_su.
 IPR019554; Soluble_ligand-bd. 

Pfam

 PF01512; Complex1_51K
 PF10589; NADH_4Fe-4S
 PF10531; SLBB 

SMART

 SM00928; NADH_4Fe-4S 

PROSITE

 PS00644; COMPLEX1_51K_1
 PS00645; COMPLEX1_51K_2 

PRINTS