CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042971
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Creatine kinase B-type 
Protein Synonyms/Alias
  
Gene Name
 CKB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
32GIWHNDNKTFLVWVNubiquitination[1, 2]
51LRVISMQKGGNMKEIubiquitination[1, 3, 4, 5]
96LRAGVHIKLPNLGKHubiquitination[1]
102IKLPNLGKHEKFSEVubiquitination[1, 3]
105PNLGKHEKFSEVLKRacetylation[6]
105PNLGKHEKFSEVLKRubiquitination[1]
111EKFSEVLKRLRLQKRubiquitination[1, 2, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 179 AA 
Protein Sequence
FLFDKPVSPL LLASGMARDW PDARGIWHND NKTFLVWVNE EDHLRVISMQ KGGNMKEIET 60
LFKSKDYEFM WNPHLGYILT CPSNLGTGLR AGVHIKLPNL GKHEKFSEVL KRLRLQKRGT 120
GGVDTAAVGG VFDVSNADRL GFSEVELVQM VVDGVKLLIE MEQRLEQGQA IDDLMPAQK 179 
Gene Ontology
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR000749; ATP-guanido_PTrfase.
 IPR022415; ATP-guanido_PTrfase_AS.
 IPR022414; ATP-guanido_PTrfase_cat.
 IPR014746; Gln_synth/guanido_kin_cat_dom. 
Pfam
 PF00217; ATP-gua_Ptrans 
SMART
  
PROSITE
 PS00112; PHOSPHAGEN_KINASE
 PS51510; PHOSPHAGEN_KINASE_C 
PRINTS