UniProt Accession

 SBDS_MOUSE; P70122; Q3TG78; Q9CR18 

Genbank Protein ID

 AK005079; AK014648; AK019228; AK168847; BC003849; X99668 

Genbank Nucleotide ID

 BAB23803.1; BAB29487.1; BAB31612.1; BAE40670.1; AAH03849.1; CAA67982.1 

Protein Name

 Ribosome maturation protein SBDS 

Protein Synonyms/Alias

 Protein 22A3; Shwachman-Bodian-Diamond syndrome protein homolog 

Gene Name

 Sbds 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
62	SVFVNVSKGQVAKKE	ubiquitination	[1]
90	ICKQILTKGEVQVSD	ubiquitination	[1]
98	GEVQVSDKERHTQLE	ubiquitination	[1]
118	IATIVADKCVNPETK	ubiquitination	[1]
151	VKPNKSTKQQALEVI	ubiquitination	[1]
159	QQALEVIKQLKEKMK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Ribosome biogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 250 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0000922; C:spindle pole; ISS:UniProtKB.
 GO:0043022; F:ribosome binding; ISS:UniProtKB.
 GO:0003723; F:RNA binding; IBA:RefGenome.
 GO:0019843; F:rRNA binding; IEA:Compara.
 GO:0048539; P:bone marrow development; IEA:Compara.
 GO:0030282; P:bone mineralization; IEA:Compara.
 GO:0001833; P:inner cell mass cell proliferation; IMP:MGI.
 GO:0030595; P:leukocyte chemotaxis; IEA:Compara.
 GO:0042256; P:mature ribosome assembly; ISS:UniProtKB.
 GO:0043148; P:mitotic spindle stabilization; IEA:Compara.
 GO:0042273; P:ribosomal large subunit biogenesis; IBA:RefGenome.
 GO:0006364; P:rRNA processing; IBA:RefGenome. 

Interpro

 IPR018978; Ribosome_mat_SBDS_C.
 IPR018023; Ribosome_mat_SBDS_CS.
 IPR019783; Ribosome_mat_SBDS_N.
 IPR002140; Ribosome_maturation_pr_SBDS. 

Pfam

 PF01172; SBDS
 PF09377; SBDS_C 

SMART

  

PROSITE

 PS01267; UPF0023 

PRINTS