CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038867
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Calcium-activated potassium channel subunit alpha-1 
Protein Synonyms/Alias
  
Gene Name
 Kcnma1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
518SIKNYHPKIRIITQMacetylation[1]
583FSMRSFIKIEEDTWQubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1058 AA 
Protein Sequence
MANGGGGGGG GSSGSSGGGG GGGGGSGLRM SSNIHANHLS LDASSSSSSS SSSSSSSSSS 60
VHEPKMDALI IPVTMEVPCD SRGQRMWWAF LASSMVTFFG GLFIILLWRT LKYLWTVCCH 120
CGGKTKEAQK INNGSSQADG TLKPVDEKEE VVAAEVGWMT SVKDWAGVMI SAQTLTGRVL 180
VVLVFALSIG ALVIYFIDSS NPIESCQNFY KDFTLQIDMA FNVFFLLYFG LRFIAANDKL 240
WFWLEVNSVV DFFTVPPVFV SVYLNRSWLG LRFLRALRLI QFSEILQFLN ILKTSNSIKL 300
VNLLSIFIST WLTAAGFIHL VENSGDPWEN FQNNQALTYW ECVYLLMVTM STVGYGDVYA 360
KTTLGRLFMV FFILGGLAMF ASYVPEIIEL IGNRKKYGGS YSAVSGRKHI VVCGHITLES 420
VSNFLKDFLH KDRDDVNVEI VFLHNISPNL ELEALFKRHF TQVEFYQGSV LNPHDLARVK 480
IESADACLIL ANKYCADPDA EDASNIMRVI SIKNYHPKIR IITQMLQYHN KAHLLNIPSW 540
NWKEGDDAIC LAELKLGFIA QSCLAQGLST MLANLFSMRS FIKIEEDTWQ KYYLEGVSNE 600
MYTEYLSSAF VGLSFPTVCE LCFVKLKLLM IAIEYKSANR ESRSLSRILI NPGNHLKIQE 660
GTLGFFIASD AKEVKRAFFY CKACHDDVTD PKRIKKCGCR RLVIAKMSIY KRMSRACCFD 720
CGRSERDCSC MSGRVRGNVD TLERNFPLSS VSVNDCSTSF RAFEDEQPPT LSPKKKQRNG 780
GMRNSPNTSP KLMRHDPLLI PGNDQIDNMD SNVKKYDSTG MFHWCAPKEI EKVILTRSEA 840
AMTVLSGHVV VCIFGDVSSA LIGLRNLVMP LRASNFHYHE LKHIVFVGSI EYLKREWETL 900
HNFPKVSILP GTPLSRADLR AVNINLCDMC VILSANQNNI DDTSLQDKEC ILASLNIKSM 960
QFDDSIGVLQ ANSQGFTPPG MDRSSPDNSP VHGMLRQPSI TTGVNIPIIT ELVNDTNVQF 1020
LDQDDDDDPD TELYLTQPFA CGTAFAVSVL DSLMSATY 1058 
Gene Ontology
 GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
 GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro.
 GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. 
Interpro
 IPR024939; Ca-act_K_channel_Slo.
 IPR005821; Ion_trans_dom.
 IPR003091; K_chnl.
 IPR003929; K_chnl_Ca-activ_BK_asu.
 IPR016040; NAD(P)-bd_dom.
 IPR003148; RCK_N. 
Pfam
 PF03493; BK_channel_a
 PF00520; Ion_trans
 PF02254; TrkA_N 
SMART
  
PROSITE
  
PRINTS
 PR01449; BKCHANNELA.
 PR00169; KCHANNEL.