CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034166
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Neurofilament medium polypeptide 
Protein Synonyms/Alias
  
Gene Name
 Nefm 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
53STVSSSYKRSALAPRubiquitination[1]
125HYLEQQNKEIEAEIQubiquitination[1]
137EIQALRQKQASHAQLubiquitination[1]
166LEMVNHEKAQVQLDSubiquitination[1]
221VKVELDKKVQSLQDEubiquitination[1]
261VERKDYLKTDISTALubiquitination[1]
269TDISTALKEIRSQLEubiquitination[1]
291HQAEEWFKCRYAKLTubiquitination[1]
296WFKCRYAKLTEAAEQubiquitination[1]
305TEAAEQNKEAIRSAKubiquitination[1]
312KEAIRSAKEEIAEYRubiquitination[1]
325YRRQLQSKSIELESVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Coiled coil; Complete proteome; Intermediate filament; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 470 AA 
Protein Sequence
MSYTLDSLGN PSAYRRVTET RSSFSRVSGS PSSGFRSQSW SRGSPSTVSS SYKRSALAPR 60
LAYSSAMLSS AESSLDFSQS SSLLNGGSGG DYKLSRSNEK EQLQGLNDRF AGYIEKVHYL 120
EQQNKEIEAE IQALRQKQAS HAQLGDAYDQ EIRELRATLE MVNHEKAQVQ LDSDHLEEDI 180
HRLKERFEEE ARLRDDTEAA IRALRKDIEE SSMVKVELDK KVQSLQDEVA FLRSNHEEEV 240
ADLLAQIQAS HITVERKDYL KTDISTALKE IRSQLECHSD QNMHQAEEWF KCRYAKLTEA 300
AEQNKEAIRS AKEEIAEYRR QLQSKSIELE SVRGTKESLE RQLSDIEERH NHDLSSYQDT 360
IQQLENELRG TKWEMARHLR EYQDLLNVKM ALDIEIAAYR LWKLRFSTNI HESSQTFEIS 420
KPLLQLLLQS FVHTPAGFDL QGLSLEQAAA FRHLVLGSAH SVGVLGGALG 470 
Gene Ontology
 GO:0005883; C:neurofilament; IDA:MGI.
 GO:0031594; C:neuromuscular junction; IDA:MGI.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0008088; P:axon cargo transport; IMP:MGI.
 GO:0045110; P:intermediate filament bundle assembly; IGI:MGI.
 GO:0000226; P:microtubule cytoskeleton organization; IGI:MGI.
 GO:0060052; P:neurofilament cytoskeleton organization; IMP:MGI.
 GO:0031133; P:regulation of axon diameter; IMP:MGI. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR006821; Intermed_filament_DNA-bd.
 IPR002957; Keratin_I. 
Pfam
 PF00038; Filament
 PF04732; Filament_head 
SMART
  
PROSITE
  
PRINTS
 PR01248; TYPE1KERATIN.