UniProt Accession

 NDEL1_HUMAN; Q9GZM8; B3KP93; D3DTS0; J3QT32; Q86T80; Q8TAR7; Q9UH50 

Genbank Protein ID

 AY004871; AF182078; AF217798; AK056014; DA256375; AL832648; AC026130; CH471108; CH471108; BC026101 

Genbank Nucleotide ID

 AAF97497.1; AAG43425.1; AAF24516.3; BAG51605.1; CAD89957.3; EAW90051.1; EAW90052.1; AAH26101.1 

Protein Name

 Nuclear distribution protein nudE-like 1 

Protein Synonyms/Alias

 Protein Nudel; Mitosin-associated protein 1 

Gene Name

 NDEL1 

Gene Synonyms/Alias

 EOPA; MITAP1; NUDEL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
269	KVGALESKLAACRNF	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. 

Sequence Annotation

 REGION 56 166 Self-association (By similarity).
 REGION 64 189 Interaction with KATNB1 (By similarity).
 REGION 114 133 Required for interaction with PAFAH1B1.
 REGION 175 345 Interaction with CENPF.
 REGION 189 256 Interaction with YWHAE (By similarity).
 REGION 191 345 Interaction with NEFL (By similarity).
 REGION 195 256 Interaction with KATNA1 (By similarity).
 REGION 241 280 Interaction with DISC1.
 REGION 256 291 Required for localization to the
 MOD_RES 215 215 Phosphoserine.
 MOD_RES 219 219 Phosphothreonine; by CDK1 and MAPK1.
 MOD_RES 242 242 Phosphoserine; by CDK1.
 MOD_RES 245 245 Phosphothreonine; by CDK1 and MAPK1.
 LIPID 273 273 S-palmitoyl cysteine; by ZDHHC2, ZDHHC3  

Keyword

 3D-structure; Alternative splicing; Centromere; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Kinetochore; Lipoprotein; Microtubule; Neurogenesis; Palmitate; Phosphoprotein; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 345 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0044297; C:cell body; IEA:Compara.
 GO:0031252; C:cell leading edge; IEA:Compara.
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005871; C:kinesin complex; IEA:Compara.
 GO:0000776; C:kinetochore; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0060053; C:neurofilament cytoskeleton; IEA:Compara.
 GO:0005635; C:nuclear envelope; IEA:Compara.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0070012; F:oligopeptidase activity; IEA:Compara.
 GO:0032864; P:activation of Cdc42 GTPase activity; IEA:Compara.
 GO:0021955; P:central nervous system neuron axonogenesis; IEA:Compara.
 GO:0051642; P:centrosome localization; IEA:Compara.
 GO:0021799; P:cerebral cortex radially oriented cell migration; IEA:Compara.
 GO:0007059; P:chromosome segregation; IMP:UniProtKB.
 GO:0001833; P:inner cell mass cell proliferation; IEA:Compara.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:Compara.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0060052; P:neurofilament cytoskeleton organization; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0051081; P:nuclear envelope disassembly; IEA:Compara.
 GO:0045773; P:positive regulation of axon extension; IEA:Compara.
 GO:0048680; P:positive regulation of axon regeneration; IEA:Compara.
 GO:0008090; P:retrograde axon cargo transport; IEA:Compara.
 GO:0047496; P:vesicle transport along microtubule; IEA:Compara. 

Interpro

 IPR006964; NUDE_C. 

Pfam

 PF04880; NUDE_C 

SMART

  

PROSITE

  

PRINTS