UniProt Accession

 CYC_HANAN; P00042 

Genbank Protein ID

  

Genbank Nucleotide ID

  

Protein Name

 Cytochrome c 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Hansenula anomala (Yeast) (Candida pelliculosa) 

NCBI Taxa ID

 4927 

Lysine Modification

Position	Peptide	Type	References
61	YTDANIKKAVEWSEQ	methylation	[1]
78	SDYLENPKKYIPGTK	methylation	[1, 2, 3, 4]
79	DYLENPKKYIPGTKM	methylation	[1]
92	KMAFGGLKKEKDRND	methylation	[1]

Reference

 [1] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681]
 [2] Method for identification and quantitative analysis of protein lysine methylation using matrix-assisted laser desorption/ionization--time-of-flight mass spectrometry and amino acid analysis.
 Yan JX, Sanchez JC, Binz PA, Williams KL, Hochstrasser DF.
 Electrophoresis. 1999 Apr-May;20(4-5):749-54. [PMID: 10344244]
 [3] Cytochrome c methyltransferase, Ctm1p, of yeast.
 Polevoda B, Martzen MR, Das B, Phizicky EM, Sherman F.
 J Biol Chem. 2000 Jul 7;275(27):20508-13. [PMID: 10791961]
 [4] Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation.
 Kluck RM, Ellerby LM, Ellerby HM, Naiem S, Yaffe MP, Margoliash E, Bredesen D, Mauk AG, Sherman F, Newmeyer DD.
 J Biol Chem. 2000 May 26;275(21):16127-33. [PMID: 10821864] 

Functional Description

 Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. 

Sequence Annotation

 METAL 24 24 Iron (heme axial ligand).
 METAL 86 86 Iron (heme axial ligand).
 BINDING 20 20 Heme (covalent).
 BINDING 23 23 Heme (covalent).
 MOD_RES 6 6 N6-acetyllysine.
 MOD_RES 61 61 N6,N6-dimethyllysine; alternate.
 MOD_RES 61 61 N6-methyllysine; alternate.
 MOD_RES 78 78 N6,N6,N6-trimethyllysine.
 MOD_RES 79 79 N6,N6,N6-trimethyllysine.  

Keyword

 Acetylation; Direct protein sequencing; Electron transport; Heme; Iron; Metal-binding; Methylation; Mitochondrion; Respiratory chain; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 109 AA 

Protein Sequence

Gene Ontology

 GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
 GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 

Interpro

 IPR002327; Cyt_c_1A/1B.
 IPR009056; Cyt_c_dom.
 IPR003088; Cyt_c_I. 

Pfam

 PF00034; Cytochrom_C 

SMART

  

PROSITE

 PS51007; CYTC 

PRINTS

 PR00604; CYTCHRMECIAB.