CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045591
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Hexokinase-1 
Protein Synonyms/Alias
  
Gene Name
 Hk1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
21LKDDQVKKIDKYLYAacetylation[1]
24DQVKKIDKYLYAMRLacetylation[1]
62YNPTASVKMLPTFVRacetylation[1]
62YNPTASVKMLPTFVRubiquitination[2]
77SIPDGSEKGDFIALDacetylation[1]
176ITWTKRFKASGVEGAacetylation[1]
187VEGADVVKLLNKAIKacetylation[1]
187VEGADVVKLLNKAIKubiquitination[2]
191DVVKLLNKAIKKRGDacetylation[1]
191DVVKLLNKAIKKRGDubiquitination[2]
392RYSRRFHKTLRRLVPacetylation[1]
444LAHFRLSKQTLMEVKacetylation[1]
451KQTLMEVKKRLRTEMubiquitination[2]
473TNSKATVKMLPSFVRubiquitination[2]
507NFRVLLVKIRGKKRTacetylation[1]
725NILIDFTKKGFLFRGacetylation[1]
725NILIDFTKKGFLFRGubiquitination[2]
726ILIDFTKKGFLFRGQacetylation[1]
739GQISEPLKTRGIFETacetylation[1]
842RIMHQTVKELSPKCTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Glycolysis; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 880 AA 
Protein Sequence
MIAAQLLAYY FTELKDDQVK KIDKYLYAMR LSDEILIDIL TRFKKEMKNG LSRDYNPTAS 60
VKMLPTFVRS IPDGSEKGDF IALDLGGSSF RILRVQVNHE KNQNVSMESE IYDTPENIVH 120
GSGTQLFDHV ADCLGDFMEK KKIKDKKLPV GFTFSFPCRQ SKIDEAVLIT WTKRFKASGV 180
EGADVVKLLN KAIKKRGDYD ANIVAVVNDT VGTMMTCGYD DQQCEVGLII GTGTNACYME 240
ELRHIDLVEG DEGRMCINTE WGAFGDDGSL EDIRTEFDRE LDRGSLNPGK QLELTSSSGH 300
LSDSHLAKDW AIKPALSPIG VFSPHWVELR ASAMLGKYST TEPHLHPVNR IELVLTRGRV 360
PSRPQLSPAV PSSPPRSPTS TSSCRYSRRF HKTLRRLVPD SDVRFLLSES GSGKGAAMVT 420
AVAYRLAEQH RQIEETLAHF RLSKQTLMEV KKRLRTEMEM GLRKETNSKA TVKMLPSFVR 480
SIPDGTEHGD FLALDLGGTN FRVLLVKIRG KKRTVEMHNK IYSIPLEIMQ GTGDELFDHI 540
VSCISDFLDY MGIKGPRMPL GFTFSFPCHQ TNLDCGILIS WTKGFKATDC EGHDVASLLR 600
DAVKRREEFD LDVVAVVNDT VGTMMTCAYE EPTCEIGLIV GTGTNACYME EMKNVEMVEG 660
NQGQMCINME WGAFGDNGCL DDIRTDFDKV VDEYSLNSGK QRFEKMISGM YLGEIVRNIL 720
IDFTKKGFLF RGQISEPLKT RGIFETKFLS QIESDRLALL QVRAILQQLG LNSTCDDSIL 780
VKTVCGVVSK RAAQLCGAGM AAVVEKIREN RGLDHLNVTV GVDGTLYKLH PHFSRIMHQT 840
VKELSPKCTV SFLLSEDGSG KGAALITAVG VRLRGDPSIA 880 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004396; F:hexokinase activity; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001312; Hexokinase.
 IPR022673; Hexokinase_C.
 IPR019807; Hexokinase_CS.
 IPR022672; Hexokinase_N. 
Pfam
 PF00349; Hexokinase_1
 PF03727; Hexokinase_2 
SMART
  
PROSITE
 PS00378; HEXOKINASES 
PRINTS
 PR00475; HEXOKINASE.