CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028755
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Scn1a 
Protein Synonyms/Alias
  
Gene Name
 Scn1a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
88DPYYINKKTFIVLNKubiquitination[1]
452QQMLEQLKKQQEAAQubiquitination[1]
453QMLEQLKKQQEAAQQubiquitination[1]
1029FIQQSFVKKQKILDEubiquitination[1]
1038QKILDEIKPLDDLNNubiquitination[1]
1501KKYYNAMKKLGSKKPubiquitination[1]
1889FMASNPSKVSYQPITubiquitination[1]
1937TYNKNKLKGGANLLVubiquitination[1]
1945GGANLLVKEDMLIDRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1998 AA 
Protein Sequence
MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK PNSDLEAGKN 60
LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF RFSATSALYI LTPFNPLRKI 120
AIKILVHSLF SMLIMCTILT NCVFMTMSNP PDWTKNVEYT FTGIYTFESL IKIIARGFCL 180
EDFTFLRDPW NWLDFTVITF AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL 240
IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCVQW PPTNASLEEH SIEKNITMDY 300
NGTLVNETVF EFDWKSYIQD SRYHYFLEGV LDALLCGNSS DAGQCPEGYM CVKAGRNPNY 360
GYTSFDTFSW AFLSLFRLMT QDFWENLYQL TLRAAGKTYM IFFVLVIFLG SFYLINLILA 420
VVAMAYEEQN QATLEEAEQK EAEFQQMLEQ LKKQQEAAQQ AAATTASEHS REPSAAGRLS 480
DSSSEASKLS SKSAKERRNR RKKRKQKEQS GGEEKDDDEF HKSESEDSIR RKGFRFSIEG 540
NRLTYEKRYS SPHQSLLSIR GSLFSPRRNS RTSLFSFRGR AKDVGSENDF ADDEHSTFED 600
NESRRDSLFV PRRHGERRNS NLSQTSRSSR MLAVFPANGK MHSTVDCNGV VSLVGGPSVP 660
TSPVGQLLPE GTTTETEMRK RRSSSFHVSM DFLEDPSQRQ RAMSIASILT NTVEELEESR 720
QKCPPCWYKF SNIFLIWDCS PYWLKVKHIV NLVVMDPFVD LAITICIVLN TLFMAMEHYP 780
MTEHFNHVLT VGNLVFTGIF TAEMFLKIIA MDPYYYFQEG WNIFDGFIVT LSLVELGLAN 840
VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK IIGNSVGALG NLTLVLAIIV FIFAVVGMQL 900
FGKSYKDCVC KIATDCKLPR WHMNDFFHSF LIVFRVLCGE WIETMWDCME VAGQAMCLTV 960
FMMVMVIGNL VVLNLFLALL LSSFSADNLA ATDDDNEMNN LQIAVDRMHK GIAYVKRKIY 1020
EFIQQSFVKK QKILDEIKPL DDLNNRKDNC ISNHTTEIGK DLDCLKDVNG TTSGIGTGSS 1080
VEKYIIDESD YMSFINNPSL TVTVPIAVGE SDFENLNTED FSSESDLEES KEKLNESSSS 1140
SEGSTVDIGA PAEEQPVIEP EETLEPEACF TEGCVQRFKC CQISVEEGRG KQWWNLRRTC 1200
FRIVEHNWFE TFIVFMILLS SGALAFEDIY IDQRKTIKTM LEYADKVFTY IFILEMLLKW 1260
VAYGYQTYFT NAWCWLDFLI VDVSLVSLTA NALGYSELGA IKSLRTLRAL RPLRALSRFE 1320
GMRVVVNALL GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYHCVNTTT GDIFEISEVN 1380
NHSDCLKLIE RNETARWKNV KVNFDNVGFG YLSLLQVATF KGWMDIMYAA VDSRNVELQP 1440
KYEESLYMYL YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM 1500
KKLGSKKPQK PIPRPGNKFQ GMVFDFVTRQ VFDISIMILI CLNMVTMMVE TDDQSDYVTS 1560
ILSRINLVFI VLFTGECVLK LISLRHYYFT IGWNIFDFVV VILSIVGMFL AELIEKYFVS 1620
PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYAIFGMSN 1680
FAYVKREVGI DDMFNFETFG NSMICLFQIT TSAGWDGLLA PILNSKPPDC DPNKVNPGSS 1740
VKGDCGNPSV GIFFFVSYII ISFLVVVNMY IAVILENFSV ATEESAEPLS EDDFEMFYEV 1800
WEKFDPDATQ FMEFEKLSQF AAALEPPLNL PQPNKLQLIA MDLPMVSGDR IHCLDILFAF 1860
TKRVLGESGE MDALRIQMEE RFMASNPSKV SYQPITTTLK RKQEEVSAVI IQRAYRRHLL 1920
KRTVKQASFT YNKNKLKGGA NLLVKEDMLI DRINENSITE KTDLTMSTAA CPPSYDRVTK 1980
PIVEKHEQEG KDEKAKGK 1998 
Gene Ontology
 GO:0043194; C:axon initial segment; IDA:MGI.
 GO:0014704; C:intercalated disc; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0033268; C:node of Ranvier; IDA:MGI.
 GO:0034706; C:sodium channel complex; IPI:MGI.
 GO:0030315; C:T-tubule; IDA:MGI.
 GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
 GO:0030018; C:Z disc; IDA:BHF-UCL.
 GO:0005248; F:voltage-gated sodium channel activity; IMP:MGI.
 GO:0007628; P:adult walking behavior; IMP:MGI.
 GO:0050884; P:neuromuscular process controlling posture; IMP:MGI.
 GO:0019227; P:neuronal action potential propagation; IMP:MGI.
 GO:0019228; P:regulation of action potential in neuron; IMP:MGI. 
Interpro
 IPR024583; DUF3451.
 IPR005821; Ion_trans_dom.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027359; K_channel_four-helix_dom.
 IPR008051; Na_channel_a1su.
 IPR001696; Na_channel_asu.
 IPR010526; Na_trans_assoc. 
Pfam
 PF11933; DUF3451
 PF00520; Ion_trans
 PF06512; Na_trans_assoc 
SMART
 SM00015; IQ 
PROSITE
  
PRINTS
 PR00170; NACHANNEL.
 PR01664; NACHANNEL1.