CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012764
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tigger transposable element-derived protein 6 
Protein Synonyms/Alias
  
Gene Name
 TIGD6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49STLSTFLKDRTKFEEubiquitination[1]
136DRHGIALKAVCREDSubiquitination[1]
513TQTLIDSKITDFLQTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
 DOMAIN 3 54 HTH psq-type.
 DOMAIN 66 137 HTH CENPB-type.
 DOMAIN 170 372 DDE.
 DNA_BIND 30 50 H-T-H motif (By similarity).
 DNA_BIND 99 130 H-T-H motif (By similarity).  
Keyword
 Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 521 AA 
Protein Sequence
MANKGNKKRR QFSLEEKMKV VGAVDSGKRK GDVAKEFGIT PSTLSTFLKD RTKFEEKVRE 60
ASVGPQRKRM RSALYDDIDK AVFAWFQEIH AKNILVTGSV IRKKALNLAN MLGYDNFQAS 120
VGWLNRFRDR HGIALKAVCR EDSDRLMNGL GIDKINEWHA GEIIKLIADY SPDDIFNADE 180
TGVFFQLLPQ HTLAAKGDHC RGGKKAKQRL TALFCCNASG TEKMRPLIVG RSASPHCLKN 240
IHSLPCDYRA NQWAWMTRDL FNEWLMQVDA RMKRAERRIL LLIDNCSAHN MLPHLERIQV 300
GYLPSNCTAV LQPLNLGIIH TMKVLYQSHL LKQILLKLNS SEDQEEVDIK QAIDMIAAAW 360
WSVKPSTVVK CWQKAGIVPM EFAECDTESA ASEPDIAIEK LWHTVAIATC VPNEVNFQDF 420
VTADDDLIIS QDTDIIQDMV AGENTSEAGS EDEGEVSLPE QPKVTITEAI SSVQKLRQFL 480
STCVDIPDAI FGQLNGIDEY LMKRVTQTLI DSKITDFLQT K 521 
Gene Ontology
 GO:0005634; C:nucleus; IDA:LIFEdb.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR004875; DDE_SF_endonuclease_CENPB-like.
 IPR009057; Homeodomain-like.
 IPR006600; HTH_CenpB_DNA-bd_dom.
 IPR007889; HTH_Psq. 
Pfam
 PF04218; CENP-B_N
 PF03184; DDE_1
 PF03221; HTH_Tnp_Tc5 
SMART
 SM00674; CENPB 
PROSITE
 PS51253; HTH_CENPB
 PS50960; HTH_PSQ 
PRINTS