| Tag | Content |
|---|
| CPLM ID | CPLM-000786 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Glucose-6-phosphate translocase |
Protein Synonyms/Alias | Glucose-5-phosphate transporter; Solute carrier family 37 member 4; Transformation-related gene 19 protein; TRG-19 |
Gene Name | SLC37A4 |
Gene Synonyms/Alias | G6PT; G6PT1; PRO0685; TRG19 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 207 | DPMPSEGKKGSLKEE | ubiquitination | [1] | | 290 | LSDRAMAKAGLSNYG | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6- phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels. |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Disease mutation; Endoplasmic reticulum; Glycogen storage disease; Membrane; Reference proteome; Sugar transport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 429 AA |
Protein Sequence | MAAQGYGYYR TVIFSAMFGG YSLYYFNRKT FSFVMPSLVE EIPLDKDDLG FITSSQSAAY 60
AISKFVSGVL SDQMSARWLF SSGLLLVGLV NIFFAWSSTV PVFAALWFLN GLAQGLGWPP 120
CGKVLRKWFE PSQFGTWWAI LSTSMNLAGG LGPILATILA QSYSWRSTLA LSGALCVVVS 180
FLCLLLIHNE PADVGLRNLD PMPSEGKKGS LKEESTLQEL LLSPYLWVLS TGYLVVFGVK 240
TCCTDWGQFF LIQEKGQSAL VGSSYMSALE VGGLVGSIAA GYLSDRAMAK AGLSNYGNPR 300
HGLLLFMMAG MTVSMYLFRV TVTSDSPKLW ILVLGAVFGF SSYGPIALFG VIANESAPPN 360
LCGTSHAIVG LMANVGGFLA GLPFSTIAKH YSWSTAFWVA EVICAASTAA FFLLRNIRTK 420
MGRVSKKAE 429 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome. GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:UniProtKB. GO:0016021; C:integral to membrane; NAS:UniProtKB. GO:0015152; F:glucose-6-phosphate transmembrane transporter activity; IDA:UniProtKB. GO:0042593; P:glucose homeostasis; IDA:UniProtKB. GO:0006006; P:glucose metabolic process; NAS:UniProtKB. GO:0015758; P:glucose transport; TAS:Reactome. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |