CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016384
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetratricopeptide repeat protein 7A 
Protein Synonyms/Alias
 TPR repeat protein 7A 
Gene Name
 Ttc7a 
Gene Synonyms/Alias
 Ttc7 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
158DDISVENKPLYQMRLubiquitination[1]
173LSEAFVIKGLSLERLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 REPEAT 122 158 TPR 1.
 REPEAT 415 448 TPR 2.
 REPEAT 498 532 TPR 3.
 REPEAT 533 566 TPR 4.
 REPEAT 567 600 TPR 5.
 REPEAT 745 778 TPR 6.
 REPEAT 779 812 TPR 7.
 REPEAT 813 846 TPR 8.
 MOD_RES 52 52 Phosphoserine (By similarity).
 MOD_RES 183 183 Phosphoserine.
 MOD_RES 648 648 Phosphoserine.
 MOD_RES 678 678 Phosphoserine.
 MOD_RES 679 679 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 858 AA 
Protein Sequence
MAAKGAHGTH LKVESEVERC RAEGQWDRMF ELARHLQMLG ISGGGSSNRR NSPSGRFTTL 60
DTDDFVKLLL AEALLEQCLK DNHDKIKNSI PLLEKTDHRL NEAKDHLSSL LNNGKLPPQY 120
MCEAMLILGK LHYVEGSYRD AVSMYARAGI DDISVENKPL YQMRLLSEAF VIKGLSLERL 180
PNSVASHIRL TEREEEVVAC FERASWVAQV FLQELEKTSN NSTSRHLKGS LSPDYELSYF 240
LEAALQSAYV KNLKKGNIVK GMRELREILR TVETKATQNF KVVAAKHLAG VLLHSLSEDC 300
YWSPLSHPLP EFMNKEENSF VTQTLRKPHL YEGDNLYCPK DNIEEALLLL LISESMATRD 360
VVLSRAPEQA EDRKVSLQNA SAIYDLLSIT LGRRGQYVML SECLERAMKC AFGEFHLWYQ 420
VALSMVACGK SAYAVSLLRE CMKLQPSDPT VPLMAAKVCI GSLHWLEEAE HFATVVIGLG 480
EEAGESLPKG YLALGLTYSL QATDATLKSK QDELHRKALQ TLERARELAP DDPQIIFYVA 540
LQLALVRQIS SAMERLQEAL TMCRDDANAL HLLALLFSAQ KYYQHALDVI NMAITEHPEN 600
FNLMFTKVKL EQVLKGPEEA LVTCRQMLRL WQTLYNFSQL GGLEKDGSFE GLTVKKQNGI 660
HLTLPDAHDA DSGSRRASSI AASRLEEAMS ELTLTTSVLK QGPMQLWTTL EQIWLQAAEL 720
FMEQRQLKEA GFCIQEAAGL FPTSHSVLYM RGRLAEVKGS FEEAKQLYKE ALTVNPDGVR 780
IMHSLGLMLS QLGHKSLAQK VLRDAVERQS TFHEAWQGLG EVLQDQGQNE AAVDCFLTAL 840
ELEASSPVLP FSIIAREL 858 
Gene Ontology
 GO:0006879; P:cellular iron ion homeostasis; IMP:MGI.
 GO:0030097; P:hemopoiesis; IMP:MGI. 
Interpro
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat.
 IPR026900; Ttc7. 
Pfam
 PF00515; TPR_1
 PF07719; TPR_2 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS