CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036912
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pyridoxal-dependent decarboxylase domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 PDXDC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18PTLAEMGKNLKEAVKubiquitination[1]
21AEMGKNLKEAVKMLEubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 760 AA 
Protein Sequence
MDASLEKIAD PTLAEMGKNL KEAVKMLEDS QRTEEENGKK LISGDIPGPL QGRIQNIGEQ 60
GHMALLGHSL GAYISTLDKE KLRKLTTRIL SDTTLWLCRI FRYENGCAYF HEEEREGLAK 120
ICRLAIHSRY EDFVVDGFNV LYNKKPVIYL SAAARPGLGQ YLCNQLGLPF PCLCRVPCNT 180
VFGSQHQMDV AFLEKLIKDD IERGRLPLLL VANAGTAAVG HTDKIGRLKE LCEQYGIWLH 240
VEGVNLATLA LGYVSSSVLA AAKCDSMTMT PGPWLGLPAV PAVTLYKHDD PALTLVAGLT 300
SNKPTDKLRA LPLWLSLQYL GLDGFVERIK HACQLSQRLQ ESLKKVNYIK ILVEDELSSP 360
VVVFRFFQEL PGSDPVFKAV PVPNMTPSGV GRERHSCDAL NRWLGEQLKQ LVPASGLTVM 420
DLEAEGTCLR FSPLMTAAVL GTRGEDVDQL VACIESKLPV LCCTLQLREE FKQEVEATAG 480
LLYVDDPNWS GIGVVRYEHA NDDKSSLKSD PEGENIHAGL LKKLNELESD LTFKIGPEYK 540
SMKSCLYVGM ASDNVDAAEL VETIAATARE IEENSRLLEN MTEVVRKGIQ EAQVELQKAS 600
EERLLEEGVL RQIPVVGSVL NWFSPVQALQ KGRTFNLTAG SLESTEPIYV YKAQGAGVTL 660
PPTPSGSRTK QRLPGQKPFK RSLRGSDALS ETSSVSHIED LEKVERLSSG PEQITLEASS 720
TEGHPGAPSP QHTDQTEAFQ KGVPHPEDDH SQVEGPESLR 760 
Gene Ontology
 GO:0016831; F:carboxy-lyase activity; IEA:InterPro.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro. 
Interpro
 IPR002129; PyrdxlP-dep_de-COase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00282; Pyridoxal_deC 
SMART
  
PROSITE
  
PRINTS