UniProt Accession

 TNR6_MOUSE; P25446; Q6GT31; Q9DCQ1 

Genbank Protein ID

 M83649; AK002590; AJ295702; AJ295703; AJ295704; DQ846748; CH466534; BC061160; S56490; S56485; S56486 

Genbank Nucleotide ID

 AAA37593.1; BAB22211.1; CAC00638.1; CAC00638.1; CAC00638.1; ABI24112.1; EDL41748.1; AAH61160.1; AAB25700.1; AAB25700.1; AAB25700.1 

Protein Name

 Tumor necrosis factor receptor superfamily member 6 

Protein Synonyms/Alias

 Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD95 

Gene Name

 Fas 

Gene Synonyms/Alias

 Apt1; Tnfrsf6 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
238	DMTIQEAKKFARENN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). 

Sequence Annotation

 REPEAT 43 79 TNFR-Cys 1.
 REPEAT 80 123 TNFR-Cys 2.
 REPEAT 124 162 TNFR-Cys 3.
 DOMAIN 222 306 Death.
 REGION 204 309 Interaction with HIPK3.
 MOD_RES 206 206 Phosphothreonine.
 MOD_RES 217 217 Phosphoserine.
 MOD_RES 220 220 Phosphoserine.
 MOD_RES 222 222 Phosphoserine.
 CARBOHYD 43 43 N-linked (GlcNAc...) (Potential).
 CARBOHYD 114 114 N-linked (GlcNAc...) (Potential).
 DISULFID 44 55 By similarity.
 DISULFID 56 69 By similarity.
 DISULFID 59 78 By similarity.
 DISULFID 81 97 By similarity.
 DISULFID 100 115 By similarity.
 DISULFID 103 123 By similarity.
 DISULFID 125 139 By similarity.
 DISULFID 142 153 By similarity.
 DISULFID 145 161 By similarity.  

Keyword

 3D-structure; Apoptosis; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0031265; C:CD95 death-inducing signaling complex; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005576; C:extracellular region; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
 GO:0006924; P:activation-induced cell death of T cells; IDA:MGI.
 GO:0019724; P:B cell mediated immunity; IMP:MGI.
 GO:0071455; P:cellular response to hyperoxia; IEA:Compara.
 GO:0071285; P:cellular response to lithium ion; IMP:MGI.
 GO:0071260; P:cellular response to mechanical stimulus; IEA:Compara.
 GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IMP:MGI.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IDA:BHF-UCL.
 GO:0010467; P:gene expression; IMP:MGI.
 GO:0002377; P:immunoglobulin production; IMP:MGI.
 GO:0006925; P:inflammatory cell apoptotic process; IDA:MGI.
 GO:0097049; P:motor neuron apoptotic process; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0050869; P:negative regulation of B cell activation; IMP:MGI.
 GO:0045060; P:negative thymic T cell selection; IMP:MGI.
 GO:0043065; P:positive regulation of apoptotic process; IGI:MGI.
 GO:0010940; P:positive regulation of necrotic cell death; IEA:Compara.
 GO:0032464; P:positive regulation of protein homooligomerization; IDA:BHF-UCL.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IC:BHF-UCL.
 GO:0051260; P:protein homooligomerization; IDA:MGI.
 GO:0045619; P:regulation of lymphocyte differentiation; IMP:MGI.
 GO:0045637; P:regulation of myeloid cell differentiation; IMP:MGI.
 GO:0003014; P:renal system process; IMP:MGI.
 GO:0051384; P:response to glucocorticoid stimulus; IMP:MGI.
 GO:0009636; P:response to toxic substance; IMP:MGI.
 GO:0048536; P:spleen development; IMP:MGI.
 GO:0006927; P:transformed cell apoptotic process; IDA:MGI. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR008063; Fas_rcpt.
 IPR001368; TNFR/NGFR_Cys_rich_reg. 

Pfam

 PF00531; Death
 PF00020; TNFR_c6 

SMART

 SM00005; DEATH
 SM00208; TNFR 

PROSITE

 PS50017; DEATH_DOMAIN
 PS00652; TNFR_NGFR_1
 PS50050; TNFR_NGFR_2 

PRINTS

 PR01680; TNFACTORR6.