| Tag | Content |
|---|
| CPLM ID | CPLM-023965 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | G-protein coupled receptor 56 |
Protein Synonyms/Alias | Protein TM7XN1; GPR56 N-terminal fragment; GPR56 NT; GPR56(N); GPR56 extracellular subunit; GPR56 subunit alpha; GPR56 C-terminal fragment; GPR56 CT; GPR56(C); GPR56 seven-transmembrane subunit; GPR56 7TM; GPR56 subunit beta |
Gene Name | GPR56 |
Gene Synonyms/Alias | TM7LN4; TM7XN1; UNQ540/PRO1083 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 286 | GRSGEAEKRLLLVDF | ubiquitination | [1] | | 302 | SQALFQDKNSSQVLG | ubiquitination | [1] | | 667 | RGGPSPLKSNSDSAR | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis. |
Sequence Annotation | DOMAIN 343 394 GPS.
CARBOHYD 39 39 N-linked (GlcNAc...) (Potential).
CARBOHYD 148 148 N-linked (GlcNAc...) (Potential).
CARBOHYD 171 171 N-linked (GlcNAc...) (Potential).
CARBOHYD 234 234 N-linked (GlcNAc...) (Potential).
CARBOHYD 303 303 N-linked (GlcNAc...) (Potential).
CARBOHYD 324 324 N-linked (GlcNAc...) (Potential).
CARBOHYD 341 341 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Disease mutation; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Secreted; Signal; Transducer; Transmembrane; Transmembrane helix; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 693 AA |
Protein Sequence | MTPQSLLQTT LFLLSLLFLV QGAHGRGHRE DFRFCSQRNQ THRSSLHYKP TPDLRISIEN 60
SEEALTVHAP FPAAHPASRS FPDPRGLYHF CLYWNRHAGR LHLLYGKRDF LLSDKASSLL 120
CFQHQEESLA QGPPLLATSV TSWWSPQNIS LPSAASFTFS FHSPPHTAAH NASVDMCELK 180
RDLQLLSQFL KHPQKASRRP SAAPASQQLQ SLESKLTSVR FMGDMVSFEE DRINATVWKL 240
QPTAGLQDLH IHSRQEEEQS EIMEYSVLLP RTLFQRTKGR SGEAEKRLLL VDFSSQALFQ 300
DKNSSQVLGE KVLGIVVQNT KVANLTEPVV LTFQHQLQPK NVTLQCVFWV EDPTLSSPGH 360
WSSAGCETVR RETQTSCFCN HLTYFAVLMV SSVEVDAVHK HYLSLLSYVG CVVSALACLV 420
TIAAYLCSRR KPRDYTIKVH MNLLLAVFLL DTSFLLSEPV ALTGSEAGCR ASAIFLHFSL 480
LTCLSWMGLE GYNLYRLVVE VFGTYVPGYL LKLSAMGWGF PIFLVTLVAL VDVDNYGPII 540
LAVHRTPEGV IYPSMCWIRD SLVSYITNLG LFSLVFLFNM AMLATMVVQI LRLRPHTQKW 600
SHVLTLLGLS LVLGLPWALI FFSFASGTFQ LVVLYLFSII TSFQGFLIFI WYWSMRLQAR 660
GGPSPLKSNS DSARLPISSG STSSSRI 687 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0004930; F:G-protein coupled receptor activity; TAS:GDB. GO:0007420; P:brain development; IMP:GDB. GO:0007155; P:cell adhesion; IDA:GDB. GO:0007267; P:cell-cell signaling; TAS:ProtInc. GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |