CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015078
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Receptor expression-enhancing protein 3 
Protein Synonyms/Alias
  
Gene Name
 REEP3 
Gene Synonyms/Alias
 C10orf74 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
90GASLIYRKFLHPLLSubiquitination[1]
99LHPLLSSKEREIDDYubiquitination[1, 2, 3]
111DDYIVQAKERGYETMubiquitination[1, 2, 4, 5, 6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 May enhance the cell surface expression of odorant receptors (By similarity). 
Sequence Annotation
 MOD_RES 150 150 Phosphoserine (By similarity).
 MOD_RES 152 152 Phosphoserine (By similarity).
 MOD_RES 201 201 Phosphothreonine.
 MOD_RES 210 210 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 255 AA 
Protein Sequence
MVSWMISRAV VLVFGMLYPA YYSYKAVKTK NVKEYVRWMM YWIVFALYTV IETVADQTVA 60
WFPLYYELKI AFVIWLLSPY TKGASLIYRK FLHPLLSSKE REIDDYIVQA KERGYETMVN 120
FGRQGLNLAA TAAVTAAVKS QGAITERLRS FSMHDLTTIQ GDEPVGQRPY QPLPEAKKKS 180
KPAPSESAGY GIPLKDGDEK TDEEAEGPYS DNEMLTHKGL RRSQSMKSVK TTKGRKEVRY 240
GSLKYKVKKR PQVYF 255 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR004345; TB2_DP1_HVA22. 
Pfam
 PF03134; TB2_DP1_HVA22 
SMART
  
PROSITE
  
PRINTS