UniProt Accession

 RUFY3_RAT; Q5FVJ0; A5HLX7; A5JUR6 

Genbank Protein ID

 EF538802; EF577045; BC089952 

Genbank Nucleotide ID

 ABP99060.1; ABQ45403.1; AAH89952.1 

Protein Name

 Protein RUFY3 

Protein Synonyms/Alias

 Rap2-interacting protein x; RIPx; Single axon-regulated protein; Singar 

Gene Name

 Rufy3 

Gene Synonyms/Alias

 Ripx 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
157	VKDLPGLKTPVGRGR	ubiquitination	[1]
249	LKDGNSSKGSEGDGQ	ubiquitination	[2]
294	ALEKSNTKLTEELAV	ubiquitination	[2]
350	SEARKHLKEETQLRL	ubiquitination	[1]
382	LAMKMLEKDVCEKQD	ubiquitination	[1]
387	LEKDVCEKQDALVSL	ubiquitination	[1]
405	LDDLRALKHELAFKL	acetylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [3] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. 

Sequence Annotation

 DOMAIN 95 227 RUN.  

Keyword

 Alternative splicing; Cell projection; Coiled coil; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Neurogenesis; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 469 AA 

Protein Sequence

Gene Ontology

 GO:0030175; C:filopodium; IDA:HGNC.
 GO:0030426; C:growth cone; IDA:HGNC.
 GO:0050771; P:negative regulation of axonogenesis; IDA:HGNC. 

Interpro

 IPR004012; Run. 

Pfam

 PF02759; RUN 

SMART

 SM00593; RUN 

PROSITE

 PS50826; RUN 

PRINTS