CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038732
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Putative ribosomal RNA methyltransferase NOP2 
Protein Synonyms/Alias
  
Gene Name
 Nop2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
72PNKSPGIKTLPGELSacetylation[1, 2, 3]
80TLPGELSKGAVQARGacetylation[2, 3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 794 AA 
Protein Sequence
MGRKLDPTKK EKRGPGRKAR KQKGAETELV RFLPAAGDEN SKRLSSRARK RAAKRRAGSV 60
DVPKPNKSPG IKTLPGELSK GAVQARGKKR PAPIQNSDGD EEEDSGEDDV VTQGDLWGSE 120
DSDEDMVDDY GAASNSEDEE EKLLPIERAA LKQKAQDATA GVLWNEEDTD EDEDDDGVSP 180
ESHPRKDDKA EGDLQINVED EEAFVLPPAG ETDQDGQAPD LQRVHKRIQD IVGVLRDFGA 240
QREEGRSRAE YLSRLQKDLA TYYSYGDFLL SKLMELFPLS ELIEFLEANE VPRPITLRTN 300
TLKTRRRDLA QALINRGVNL DPLGKWSKSG LVVYDSSVPI GATPEYLAGH YMLQGASSML 360
PVMALAPQEH ERILDMCCAP GGKTSYIAQL MKNTGVILAN DANADRLKSV VGNLHRLGVT 420
NTIISHYDGR QFPKVVGGFD RVLLDAPCSG TGVISKDPAV KTNKDEKDIQ RCAHLQKELL 480
LSAIDSVNAA SKTGGYLVYC TCSITVEENE WVVDYALKKR NVRLVPTGLD FGQEGFTRFQ 540
ARRFHPTLRS TRRFYPHTHN MDGFFIAKFK KFSNSIPQPH AGNSAAATPT EPDLKDQVTP 600
KSENGSQPTK KARGAVKAKQ QLLRQPHSKK PFQKLNGIAK GPGLSTEPSV PDAQVSTRPS 660
QSAGNADVNS KRKRSEKLKQ RGPKWKPSKE AAVPKPSAPS RVEDSRTPPV PTPSEIRAAP 720
RPKDCAPSLG EAKKKQKGKQ QLAQQPANGA APLKEDAVSK GPSAPFVSPH SSTRPPPAKR 780
RKSMTKGNSQ PLLS 794 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
 GO:0032259; P:methylation; IEA:GOC.
 GO:0006364; P:rRNA processing; IEA:InterPro. 
Interpro
 IPR001678; Fmu/NOL1/Nop2p.
 IPR018314; Fmu/NOL1/Nop2p_CS.
 IPR011023; Nop2p.
 IPR012586; P120R.
 IPR023267; RCMT.
 IPR023273; RCMT_NOP2. 
Pfam
 PF01189; Nol1_Nop2_Fmu
 PF08062; P120R 
SMART
  
PROSITE
 PS01153; NOL1_NOP2_SUN 
PRINTS
 PR02008; RCMTFAMILY.
 PR02012; RCMTNOP2.