UniProt Accession

 AN32E_RAT; Q5XIE0 

Genbank Protein ID

 BC083744 

Genbank Nucleotide ID

 AAH83744.1 

Protein Name

 Acidic leucine-rich nuclear phosphoprotein 32 family member E 

Protein Synonyms/Alias

  

Gene Name

 Anp32e 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MEMKKKINMEL	acetylation	[1]
5	***MEMKKKINMELK	acetylation	[1]
6	**MEMKKKINMELKN	acetylation	[1]
65	ARLPSLNKLRKLELS	acetylation	[1]
113	VEALQNLKNLKSLDL	acetylation	[1]
113	VEALQNLKNLKSLDL	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis process by modulating PP2A activity (By similarity). 

Sequence Annotation

 REPEAT 18 38 LRR 1.
 REPEAT 43 64 LRR 2.
 REPEAT 65 87 LRR 3.
 REPEAT 89 110 LRR 4.
 DOMAIN 123 161 LRRCT.  

Keyword

 Complete proteome; Cytoplasm; Leucine-rich repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 258 AA 

Protein Sequence

Gene Ontology

 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0019212; F:phosphatase inhibitor activity; IEA:Compara. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003603; U2A'_phosphoprotein32A_C. 

Pfam

 PF12799; LRR_4 

SMART

 SM00446; LRRcap 

PROSITE

 PS51450; LRR 

PRINTS