| Tag | Content |
|---|
| CPLM ID | CPLM-005305 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cytochrome P450 2C23 |
Protein Synonyms/Alias | Arachidonic acid epoxygenase; CYPIIC23 |
Gene Name | Cyp2c23 |
Gene Synonyms/Alias | Cyp2c-23 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 346 | QPPSMKDKMKLPYTD | acetylation | [1] | | 436 | FVPFSLGKRACVGES | acetylation | [1] | | 463 | LLQKFSLKTLVEPKD | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Predominant enzyme isoform responsible for arachidonic acid epoxidation in the rat kidney. Catalyzes the NADPH-dependent metabolism of arachidonic acid to a mixture of 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETS) as the only oxygenation products. Low rate of lauric acid hydroxylation at the (omega-1)- position. |
Sequence Annotation | METAL 439 439 Iron (heme axial ligand) (By similarity). |
Keyword | Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 494 AA |
Protein Sequence | MELLGFTTLA LVVSVTCLSL LSVWTKLRTR GRLPPGPTPL PIIGNLLQLN LKDIPASLSK 60
LAKEYGPVYT LYFGTSPTVV LHGYDVVKEA LLQQGDEFLG RGPLPIIEDT HKGYGLIFSN 120
GERWKVMRRF SLMTLRNFGM GKRSLEERVQ EEARCLVEEL QKTKAQPFDP TFILACAPCN 180
VICSILFNDR FQYNDKTFLN LMDLLNKNFQ QVNSVWCQMY NLWPTIIKYL PGKHIEFAKR 240
IDDVKNFILE KVKEHQKSLD PANPRDYIDC FLSKIEEEKD NLKSEFHLEN LAVCGSNLFT 300
AGTETTSTTL RFGLLLLMKY PEVQAKVHEE LDRVIGRHQP PSMKDKMKLP YTDAVLHEIQ 360
RYITLLPSSL PHAVVQDTKF RDYVIPKGTT VLPMLSSVML DQKEFANPEK FDPGHFLDKN 420
GCFKKTDYFV PFSLGKRACV GESLARMELF LFFTTLLQKF SLKTLVEPKD LDIKPITTGI 480
INLPPPYKLC LVPR 494 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD. GO:0008392; F:arachidonic acid epoxygenase activity; IDA:RGD. GO:0070330; F:aromatase activity; IEA:EC. GO:0009055; F:electron carrier activity; IEA:InterPro. GO:0020037; F:heme binding; IEA:InterPro. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0019369; P:arachidonic acid metabolic process; NAS:RGD. GO:0033574; P:response to testosterone stimulus; IEP:RGD. |
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