UniProt Accession

 MCES_DROME; Q9VJQ4; Q9N6X4 

Genbank Protein ID

 AE014134; AY071407 

Genbank Nucleotide ID

 AAF53430.2; AAL49029.1 

Protein Name

 mRNA cap guanine-N7 methyltransferase 

Protein Synonyms/Alias

 mRNA (guanine-N(7)-)-methyltransferase 

Gene Name

 l(2)35Bd 

Gene Synonyms/Alias

 CG3688 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
104	RKDRQKSKIFFMRNF	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity). 

Sequence Annotation

 DOMAIN 64 420 mRNA cap 0 methyltransferase.
 REGION 112 113 mRNA cap binding (By similarity).
 REGION 202 203 S-adenosyl-L-methionine binding (By
 REGION 225 227 S-adenosyl-L-methionine binding (By
 BINDING 116 116 S-adenosyl-L-methionine (By similarity).
 BINDING 143 143 S-adenosyl-L-methionine; via carbonyl
 BINDING 165 165 S-adenosyl-L-methionine (By similarity).
 BINDING 229 229 mRNA cap (By similarity).
 BINDING 314 314 mRNA cap (By similarity).
 BINDING 403 403 mRNA cap (By similarity).
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 24 24 Phosphoserine.
 MOD_RES 29 29 Phosphoserine.
 MOD_RES 46 46 Phosphoserine.
 MOD_RES 48 48 Phosphoserine.  

Keyword

 Complete proteome; Methyltransferase; mRNA capping; mRNA processing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 427 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0004482; F:mRNA (guanine-N7-)-methyltransferase activity; ISS:UniProtKB.
 GO:0003723; F:RNA binding; ISS:UniProtKB. 

Interpro

 IPR016899; mRNA_G-N7_MeTrfase.
 IPR004971; mRNA_G-N7_MeTrfase_dom. 

Pfam

 PF03291; Pox_MCEL 

SMART

  

PROSITE

 PS51562; RNA_CAP0_MT 

PRINTS