CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022673
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acyl-protein thioesterase 2 
Protein Synonyms/Alias
 APT-2; Lysophospholipase 2; Lysophospholipase II; LPL-II; LysoPLA II 
Gene Name
 Lypla2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
53TIRLPHVKYICPHAPacetylation[1]
108ALIEHEMKNGIPANRacetylation[1]
203TPARVQFKTYPGVMHubiquitination[2]
226AVKEFLEKLLPPV**acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Has lysophospholipase activity. Deacylates GAP43 (By similarity). 
Sequence Annotation
 ACT_SITE 122 122 Charge relay system (By similarity).
 ACT_SITE 176 176 Charge relay system (By similarity).
 ACT_SITE 210 210 Charge relay system (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid metabolism; Hydrolase; Lipid metabolism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 231 AA 
Protein Sequence
MCGNNMSVPL LTDAATVSGA ERETAAVIFL HGLGDTGHSW ADALSTIRLP HVKYICPHAP 60
RIPVTLNMKM VMPSWFDLMG LSPDAPEDEA GIKKAAENIK ALIEHEMKNG IPANRIVLGG 120
FSQGGALSLY TALTCPHPLA GIVALSCWLP LHRNFPQAAN GSAKDLAILQ CHGELDPMVP 180
VRFGALTAEK LRTVVTPARV QFKTYPGVMH SSCPQEMAAV KEFLEKLLPP V 231 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW. 
Interpro
 IPR003140; PLipase/COase/thioEstase. 
Pfam
 PF02230; Abhydrolase_2 
SMART
  
PROSITE
  
PRINTS