| Tag | Content |
|---|
| CPLM ID | CPLM-013894 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 1-deoxy-D-xylulose-5-phosphate synthase |
Protein Synonyms/Alias | 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS |
Gene Name | dxs |
Gene Synonyms/Alias | TTHA0006 |
Created Date | July 27, 2013 |
Organism | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
NCBI Taxa ID | 300852 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 202 | KWVQDAEKLGKNILE | acetylation | [1] |
|
Reference | [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus. Okanishi H, Kim K, Masui R, Kuramitsu S. J Proteome Res. 2013 Aug 1;. [ PMID: 23901841] |
Functional Description | Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity). |
Sequence Annotation | REGION 113 115 Thiamine pyrophosphate binding (By
REGION 145 146 Thiamine pyrophosphate binding (By
METAL 144 144 Magnesium (By similarity).
METAL 173 173 Magnesium (By similarity).
BINDING 72 72 Thiamine pyrophosphate (By similarity).
BINDING 173 173 Thiamine pyrophosphate (By similarity).
BINDING 281 281 Thiamine pyrophosphate (By similarity).
BINDING 360 360 Thiamine pyrophosphate (By similarity). |
Keyword | Complete proteome; Isoprene biosynthesis; Magnesium; Metal-binding; Reference proteome; Thiamine biosynthesis; Thiamine pyrophosphate; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 615 AA |
Protein Sequence | MILDKVNSPE DLKRLSLEEL LLLAEEIRSE IIRVTAQNGG HLASSLGAVE LVLALHRVFD 60
SPRDRILFDV GHQAYAHKLV TGRKDRFHTL RKEGGISGFT KVSESPHDAI TAGHASTSLA 120
NALGMVLARD LMGEDYHVVA VIGDGALTGG MALAALNKIG ELQKRMLIVL NDNEMSISEN 180
VGALNKYFKE LQIRKWVQDA EKLGKNILER ISPQLFGLVD RAKEAAKFLL HQENPFYAWG 240
IRYVGPVDGH DLKGLVHILE HLKALDGPTL LHVVTKKGKG YKVAEADPIY WHGPPGFDPK 300
KPEKVSKGYT WSQAFGDAVT ELAHMEPRLF VLTPAMREGS GLVRYSLEHP ERYLDVGICE 360
DVAVTTAAGL ALRGMKPIVA IYSTFLQRAY DQVIHDVAIE NLPVVFAIDR AGIVGADGAT 420
HHGVFDIAYL RTVPNLQIAA PKDALELRAM LKKALEVGGP VAIRYPRDNV ERAPEGVWPE 480
IAWGKWEVLK EGTEAYILAF GKTLRYALEA AGDDPRVGVV NARFLKPLDR EMLRELSRYK 540
LLTVEDHQKM GGFGSAVLEA LNEMGLKPEV QILGLPDRFF EHGAIPSLHR QAGIDAEGIR 600
KALAAMGVAL VHERA 615 |
Gene Ontology | GO:0008661; F:1-deoxy-D-xylulose-5-phosphate synthase activity; IEA:HAMAP. GO:0000287; F:magnesium ion binding; IEA:HAMAP. GO:0030976; F:thiamine pyrophosphate binding; IEA:HAMAP. GO:0052865; P:1-deoxy-D-xylulose 5-phosphate biosynthetic process; IEA:UniProtKB-UniPathway. GO:0016114; P:terpenoid biosynthetic process; IEA:HAMAP. GO:0009228; P:thiamine biosynthetic process; IEA:HAMAP. |
Interpro | |
Pfam | |
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PROSITE | |
PRINTS | |