CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003958
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrin alpha-5 
Protein Synonyms/Alias
 CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain 
Gene Name
 Itga5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1042PYGTAMEKAQLKPPAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. May play a role in the survival of adult skeletal muscle. 
Sequence Annotation
 REPEAT 46 111 FG-GAP 1.
 REPEAT 131 191 FG-GAP 2.
 REPEAT 196 248 FG-GAP 3.
 REPEAT 262 318 FG-GAP 4.
 REPEAT 319 380 FG-GAP 5.
 REPEAT 381 440 FG-GAP 6.
 REPEAT 444 507 FG-GAP 7.
 MOTIF 1024 1028 GFFKR motif.
 METAL 283 283 Calcium 1 (By similarity).
 METAL 285 285 Calcium 1 (By similarity).
 METAL 287 287 Calcium 1 (By similarity).
 METAL 289 289 Calcium 1; via carbonyl oxygen (By
 METAL 291 291 Calcium 1 (By similarity).
 METAL 337 337 Calcium 2 (By similarity).
 METAL 339 339 Calcium 2 (By similarity).
 METAL 341 341 Calcium 2 (By similarity).
 METAL 343 343 Calcium 2; via carbonyl oxygen (By
 METAL 345 345 Calcium 2 (By similarity).
 METAL 404 404 Calcium 3 (By similarity).
 METAL 406 406 Calcium 3 (By similarity).
 METAL 408 408 Calcium 3 (By similarity).
 METAL 410 410 Calcium 3; via carbonyl oxygen (By
 METAL 412 412 Calcium 3 (By similarity).
 METAL 468 468 Calcium 4 (By similarity).
 METAL 470 470 Calcium 4 (By similarity).
 METAL 472 472 Calcium 4 (By similarity).
 METAL 474 474 Calcium 4; via carbonyl oxygen (By
 METAL 476 476 Calcium 4 (By similarity).
 BINDING 265 265 Arg of R-G-D substrate (By similarity).
 BINDING 272 272 Arg of R-G-D substrate (By similarity).
 CARBOHYD 87 87 N-linked (GlcNAc...) (Potential).
 CARBOHYD 185 185 N-linked (GlcNAc...).
 CARBOHYD 300 300 N-linked (GlcNAc...).
 CARBOHYD 310 310 N-linked (GlcNAc...).
 CARBOHYD 319 319 N-linked (GlcNAc...) (Potential).
 CARBOHYD 527 527 N-linked (GlcNAc...) (Potential).
 CARBOHYD 533 533 N-linked (GlcNAc...) (Potential).
 CARBOHYD 596 596 N-linked (GlcNAc...).
 CARBOHYD 612 612 N-linked (GlcNAc...).
 CARBOHYD 675 675 N-linked (GlcNAc...); atypical.
 CARBOHYD 678 678 N-linked (GlcNAc...).
 CARBOHYD 685 685 N-linked (GlcNAc...); atypical.
 CARBOHYD 715 715 N-linked (GlcNAc...).
 CARBOHYD 727 727 N-linked (GlcNAc...).
 CARBOHYD 776 776 N-linked (GlcNAc...) (Potential).
 CARBOHYD 872 872 N-linked (GlcNAc...) (Potential).
 CARBOHYD 876 876 N-linked (GlcNAc...).
 DISULFID 102 111 By similarity.
 DISULFID 159 179 By similarity.
 DISULFID 195 208 By similarity.
 DISULFID 516 525 By similarity.
 DISULFID 531 587 By similarity.
 DISULFID 648 654 By similarity.
 DISULFID 721 734 By similarity.
 DISULFID 873 915 Interchain (between heavy and light
 DISULFID 920 925 By similarity.  
Keyword
 Calcium; Cell adhesion; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; Glycoprotein; Integrin; Membrane; Metal-binding; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1053 AA 
Protein Sequence
MGSWTPRSPR SPLHAVLLRW GPRRLPPLLP LLLLLWPPPL QVGGFNLDAE APAVLSGPPG 60
SLFGFSVEFY RPGRDGVSVL VGAPKANTSQ PGVLQGGAVY VCPWGTSPIQ CTTIQFDSKG 120
SRILESSLYS AKGEEPVEYK SLQWFGATVR AHGSSILACA PLYSWRTEKD PQNDPVGTCY 180
LSTENFTRIL EYAPCRSDFG SAAGQGYCQG GFSAEFTKTG RVVLGGPGSY FWQGQILSAT 240
QEQISESYYP EYLINPVQGQ LQTRQASSVY DDSYLGYSVA VGEFSGDDTE DFVAGVPKGN 300
LTYGYVTVLN GSDIHSLYNV SGEQMASYFG YAVAATDTNG DGLDDLLVGA PLLMERTADG 360
RPQEVGRVYI YLQRPAGIDP TPTLTLTGQD EFSRFGSSLT PLGDLDQDGY NDVAIGAPFG 420
GEAQQGVVFI FPGGPGGLST KPSQVLQPLW AAGRTPDFFG SALRGGRDLD GNGYPDLIVG 480
SFGVDKALVY RGRPIISASA SLTIFPSMFN PEERSCSLEG NPVSCINLSF CLNASGKHVP 540
NSIGFEVELQ LDWQKQKGGV RRALFLTSKQ ATLTQTLLIQ NGAREDCREM KIYLRNESEF 600
RDKLSPIHIA LNFSLDPKAP MDSHGLRPVL HYQSKSRIED KAQILLDCGE DNICVPDLQL 660
DVYGEKKHVY LGDKNALNLT FHAQNLGEGG AYEAELRVTA PLEAEYSGLV RHPGNFSSLS 720
CDYFAVNQSR QLVCDLGNPM KAGTSLWGGL RFTVPHLQDT KKTIQFDFQI LSKNLNNSQS 780
NVVSFPLSVE AQAQVSLNGV SKPEAVIFPV SDWNPQDQPQ KEEDLGPAVH HVYELINQGP 840
SSISQGVLEL SCPQALEGQQ LLYVTKVTGL SNCTSNYTPN SQGLELDPET SPHHLQKREA 900
PGRSSTASGT QVLKCPEAKC FRLRCEFGPL HRQESRSLQL HFRVWAKTFL QREYQPFSLQ 960
CEAVYEALKM PYQILPRQLP QKKLQVATAV QWTKAEGSNG VPLWIIILAI LFGLLLLGLL 1020
IYVLYKLGFF KRSLPYGTAM EKAQLKPPAT SDA 1053 
Gene Ontology
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0008305; C:integrin complex; IEA:InterPro.
 GO:0032587; C:ruffle membrane; IEA:Compara.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0033631; P:cell-cell adhesion mediated by integrin; IMP:MGI.
 GO:0007044; P:cell-substrate junction assembly; IDA:MGI.
 GO:0007157; P:heterophilic cell-cell adhesion; IMP:MGI.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0007159; P:leukocyte cell-cell adhesion; IMP:MGI.
 GO:0007613; P:memory; IMP:MGI.
 GO:2000811; P:negative regulation of anoikis; IEA:Compara.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0035313; P:wound healing, spreading of epidermal cells; IEA:Compara. 
Interpro
 IPR013517; FG-GAP.
 IPR013519; Int_alpha_beta-p.
 IPR000413; Integrin_alpha.
 IPR013649; Integrin_alpha-2.
 IPR018184; Integrin_alpha_C_CS. 
Pfam
 PF01839; FG-GAP
 PF08441; Integrin_alpha2 
SMART
 SM00191; Int_alpha 
PROSITE
 PS51470; FG_GAP
 PS00242; INTEGRIN_ALPHA 
PRINTS
 PR01185; INTEGRINA.