CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031441
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho GTPase-activating protein 11A 
Protein Synonyms/Alias
 cDNA FLJ50314, highly similar to Homo sapiens Rho GTPase activating protein 11A (ARHGAP11A), transcript variant 1, mRNA; cDNA, FLJ79336, highly similar to Homo sapiens Rho GTPase activating protein 11A (ARHGAP11A), transcript variant 1, mRNA 
Gene Name
 ARHGAP11A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
249VRRSLRLKFNLGKNGubiquitination[1]
282LANQQSLKNRIESVKubiquitination[2]
541IKKQQSPKDKLNNKLacetylation[3]
830TQLLPTSKPVDL***acetylation[4]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 834 AA 
Protein Sequence
MDSSNLAVIF APNLLQTSEG HEKMSSNTEK KLRLQAAVVQ TLIDYASDIG RVPDFILEKI 60
PAMLGIDGLC ATPSLEGFEE GEYETPGEYK RKRRQSVGDF VSGALNKFKP NRTPSITPQE 120
ERIAQLSESP VILTPNAKRT LPVDSSHGFS SKKRKSIKHN FNFELLPSNL FNSSSTPVSV 180
HIDTSSEGSS QSSLSPVLIG GNHLITAGVP RRSKRIAGKK VCRVESGKAG CFSPKISHKE 240
KVRRSLRLKF NLGKNGREVN GCSGVNRYES VGWRLANQQS LKNRIESVKT GLLFSPDVDE 300
KLPKKGSEKI SKSEETLLTP ERLVGTNYRM SWTGPNNSSF QEVDANEASS MVENLEVENS 360
LEPDIMVEKS PATSCELTPS NLNNKHNSNI TSSPLSGDEN NMTKETLVKV QKAFSESGSN 420
LHALMNQRQS SVTNVGKVKL TEPSYLEDSP EENLFETNDL TIVESKEKYE HHTGKGEKCF 480
SERDFSPLQT QTFNRETTIK CYSTQMKMEH EKDIHSNMPK DYLSKQEFSS DEEIKKQQSP 540
KDKLNNKLKE NENMMEGNLP KCAAHSKDEA RSSFSQQSTC VVTNLSKPRP MRIAKQQSLE 600
TCEKTVSESS QMTEHRKVSD HIQWFNKLSL NEPNRIKVKS PLKFQRTPVR QSVRRINSLL 660
EYSRQPTGHK LASLGDTASP LVKSVSCDGA LSSCIESASK DSSVSCIKSG PKEQKSMSCE 720
ESNIGAISKS SMELPSKSFL KMRKHPDSVN ASLRSTTVYK QKILSDGQVK VPLDDLTNHD 780
IVKPVVNNNM GISSGINNRV LRRPSERGRA WYKGSPKHPI GKTQLLPTSK PVDL 834 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
  
SMART
  
PROSITE
 PS50238; RHOGAP 
PRINTS