| Tag | Content |
|---|
| CPLM ID | CPLM-017842 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquilin-1 |
Protein Synonyms/Alias | Protein linking IAP with cytoskeleton 1; PLIC-1 |
Gene Name | Ubqln1 |
Gene Synonyms/Alias | Plic1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 36 | KVTVKTPKEKEEFAV | ubiquitination | [1] | | 38 | TVKTPKEKEEFAVPE | ubiquitination | [1] | | 53 | NSSVQQFKEEISKRF | ubiquitination | [1] | | 58 | QFKEEISKRFKSHID | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors. Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation (By similarity). |
Sequence Annotation | DOMAIN 28 102 Ubiquitin-like.
DOMAIN 539 579 UBA.
MOD_RES 2 2 N-acetylalanine (By similarity). |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Proteasome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 582 AA |
Protein Sequence | MAESAESGGP PGAQDSAADG GPAEPKIMKV TVKTPKEKEE FAVPENSSVQ QFKEEISKRF 60
KSHIDQLVLI FAGKILKDQD TLSQHGIHDG LTVHLVIKTQ NRPQDNSAQQ TNAPGSTVTS 120
SPAPDSNPTS GSAANSSFGV GGLGGLAGLS SLGLNTTNFS ELQSQMQRQL LSNPEMMVQI 180
MENPFVQSML SNPDLMRQLI MANPQMQQLI QRNPEISHML NNPDIMRQTL ELARNPAMMQ 240
EMMRNQDRAL SNLESIPGGY NALRRMYTDI QEPMLNAAQE QFGGNPFASL VSSSSSAEGT 300
QPSRTENRDP LPNPWAPQTS QSSPASGTTG STTNTMSTSG GTATSTPAGQ STSGPSLVPG 360
AGASMFNTPG MQSLLQQITE NPQLMQNMLS APYMRSMLQS LSQNPDLAAQ MMLNNPLFAG 420
NPQLQEQMRQ QLPTFLQQMQ NPDTLSAMSN PRAMQALLQI QQGLQTLATE APGLIPGFTP 480
GLAAGNSGGS SGTNAPSTAP SEDTNPQGGT AEPGHQQFIQ QMLQALAGVN PQLQSPEVRF 540
QQQLEQLSAM GFLNREANLQ ALIATGGDIN AAIERLLGSQ PS 582 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; ISS:HGNC. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0048471; C:perinuclear region of cytoplasm; ISS:HGNC. GO:0000502; C:proteasome complex; IEA:UniProtKB-KW. GO:0019215; F:intermediate filament binding; NAS:UniProtKB. GO:0019900; F:kinase binding; ISS:UniProtKB. GO:0005102; F:receptor binding; NAS:UniProtKB. GO:0071456; P:cellular response to hypoxia; ISS:BHF-UCL. GO:0097194; P:execution phase of apoptosis; ISS:BHF-UCL. GO:0031396; P:regulation of protein ubiquitination; ISS:HGNC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |