CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027403
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 M1-family aminopeptidase 
Protein Synonyms/Alias
  
Gene Name
 MAL13P1.56 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
143EENTCSDKRMKPFEEacetylation[1]
146TCSDKRMKPFEEGHGacetylation[1]
756EERILLLKYDSDAFVacetylation[1]
954DKTYKLSKDDELLLQacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminopeptidase; Complete proteome; Hydrolase; Protease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1085 AA 
Protein Sequence
MKLTKGCAYK YIIFTVLILA NILYDNKKRC MIKKNLRISS CGIISRLLKS NSNYNSFNKN 60
YNFTSAISEL QFSNFWNLDI LQKDIFSNIH NNKNKPQSYI IHKRLMSEKG DNNNNNHQNN 120
NGNDNKKRLG SVVNNEENTC SDKRMKPFEE GHGITQVDKM NNNSDHLQQN GVMNLNSNNV 180
ENNNNNNSVV VKKNEPKIHY RKDYKPSGFI INNVTLNINI HDNETIVRSV LDMDISKHNV 240
GEDLVFDGVG LKINEISINN KKLVEGEEYT YDNEFLTIFS KFVPKSKFAF SSEVIIHPET 300
NYALTGLYKS KNIIVSQCEA TGFRRITFFI DRPDMMAKYD VTVTADKEKY PVLLSNGDKV 360
NEFEIPGGRH GARFNDPHLK PCYLFAVVAG DLKHLSATYI TKYTKKKVEL YVFSEEKYVS 420
KLQWALECLK KSMAFDEDYF GLEYDLSRLN LVAVSDFNVG AMENKGLNIF NANSLLASKK 480
NSIDFSYARI LTVVGHEYFH NYTGNRVTLR DWFQLTLKEG LTVHRENLFS EEMTKTVTTR 540
LSHVDLLRSV QFLEDSSPLS HPIRPESYVS MENFYTTTVY DKGSEVMRMY LTILGEEYYK 600
KGFDIYIKKN DGNTATCEDF NYAMEQAYKM KKADNSANLN QYLLWFSQSG TPHVSFKYNY 660
DAEKKQYSIH VNQYTKPDEN QKEKKPLFIP ISVGLINPEN GKEMISQTTL ELTKESDTFV 720
FNNIAVKPIP SLFRGFSAPV YIEDNLTDEE RILLLKYDSD AFVRYNSCTN IYMKQILMNY 780
NEFLKAKNEK LESFNLTPVN AQFIDAIKYL LEDPHADAGF KSYIVSLPQD RYIINFVSNL 840
DTDVLADTKE YIYKQIGDKL NDVYYKMFKS LEAKADDLTY FNDESHVDFD QMNMRTLRNT 900
LLSLLSKAQY PNILNEIIEH SKSPYPSNWL TSLSVSAYFD KYFELYDKTY KLSKDDELLL 960
QEWLKTVSRS DRKDIYEILK KLENEVLKDS KNPNDIRAVY LPFTNNLRRF HDISGKGYKL 1020
IAEVITKTDK FNPMVATQLC EPFKLWNKLD TKRQELMLNE MNTMLQEPNI SNNLKEYLLR 1080
LTNKL 1085 
Gene Ontology
 GO:0020011; C:apicoplast; ISS:GeneDB_Pfalciparum.
 GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
 GO:0004222; F:metalloendopeptidase activity; ISS:GeneDB_Pfalciparum.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR001930; Peptidase_M1.
 IPR014782; Peptidase_M1_N.
 IPR012779; Peptidase_M1_pepN.
 IPR024601; Peptidase_M1_pepN_C. 
Pfam
 PF11940; DUF3458
 PF01433; Peptidase_M1 
SMART
  
PROSITE
  
PRINTS
 PR00756; ALADIPTASE.