UniProt Accession

 BNIP2_HUMAN; Q12982; B4DS94 

Genbank Protein ID

 U15173; AK299628; AY268590; AC092755; BC002461 

Genbank Nucleotide ID

 AAC00021.1; BAG61556.1; AAP03429.1; AAH02461.1 

Protein Name

 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 

Protein Synonyms/Alias

  

Gene Name

 BNIP2 

Gene Synonyms/Alias

 NIP2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
174	KTTEVIRKGSITEYT	ubiquitination	[1]
186	EYTAAEEKEDGRRWR	ubiquitination	[1]
207	QDHRVDMKAIEPYKK	ubiquitination	[1]
214	KAIEPYKKVISHGGY	ubiquitination	[1]
281	NGATTRRKMPSLGWL	ubiquitination	[1, 2]
290	PSLGWLRKCYQQIDR	ubiquitination	[1]
329	TRPFISSKFSQKIRY	ubiquitination	[1, 2, 3]
333	ISSKFSQKIRYVFNL	ubiquitination	[1]
368	VDQELNGKQDEPKNE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins. 

Sequence Annotation

 DOMAIN 147 304 CRAL-TRIO.
 MOD_RES 114 114 Phosphoserine.  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 314 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005635; C:nuclear envelope; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; TAS:UniProtKB.
 GO:0005096; F:GTPase activator activity; TAS:ProtInc.
 GO:0006915; P:apoptotic process; IPI:MGI.
 GO:0042692; P:muscle cell differentiation; TAS:Reactome.
 GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB.
 GO:0051149; P:positive regulation of muscle cell differentiation; TAS:Reactome. 

Interpro

 IPR022181; Bcl2-/adenovirus-E1B.
 IPR001251; CRAL-TRIO_dom. 

Pfam

 PF12496; BNIP2 

SMART

 SM00516; SEC14 

PROSITE

 PS50191; CRAL_TRIO 

PRINTS