| Tag | Content |
|---|
| CPLM ID | CPLM-006211 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | S-(hydroxymethyl)glutathione dehydrogenase |
Protein Synonyms/Alias | Alcohol dehydrogenase SFA; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; FLD; GSH-FDH |
Gene Name | SFA1 |
Gene Synonyms/Alias | SFA; YDL168W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 124 | AVRATQGKGVMPDGT | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Oxidizes long-chain alcohols and, in the presence of glutathione, is able to oxidize formaldehyde. Is responsible for yeast resistance to formaldehyde. |
Sequence Annotation | METAL 49 49 Zinc 1; catalytic (By similarity).
METAL 71 71 Zinc 1; catalytic (By similarity).
METAL 101 101 Zinc 2 (By similarity).
METAL 104 104 Zinc 2 (By similarity).
METAL 107 107 Zinc 2 (By similarity).
METAL 115 115 Zinc 2 (By similarity).
METAL 179 179 Zinc 1; catalytic (By similarity). |
Keyword | Complete proteome; Metal-binding; NAD; Oxidoreductase; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 386 AA |
Protein Sequence | MSAATVGKPI KCIAAVAYDA KKPLSVEEIT VDAPKAHEVR IKIEYTAVCH TDAYTLSGSD 60
PEGLFPCVLG HEGAGIVESV GDDVITVKPG DHVIALYTAE CGKCKFCTSG KTNLCGAVRA 120
TQGKGVMPDG TTRFHNAKGE DIYHFMGCST FSEYTVVADV SVVAIDPKAP LDAACLLGCG 180
VTTGFGAALK TANVQKGDTV AVFGCGTVGL SVIQGAKLRG ASKIIAIDIN NKKKQYCSQF 240
GATDFVNPKE DLAKDQTIVE KLIEMTDGGL DFTFDCTGNT KIMRDALEAC HKGWGQSIII 300
GVAAAGEEIS TRPFQLVTGR VWKGSAFGGI KGRSEMGGLI KDYQKGALKV EEFITHRRPF 360
KEINQAFEDL HNGDCLRTVL KSDEIK 386 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:SGD. GO:0004022; F:alcohol dehydrogenase (NAD) activity; IDA:SGD. GO:0033833; F:hydroxymethylfurfural reductase (NADH) activity; IMP:SGD. GO:0051903; F:S-(hydroxymethyl)glutathione dehydrogenase activity; IDA:SGD. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0000947; P:amino acid catabolic process to alcohol via Ehrlich pathway; IGI:SGD. GO:0006069; P:ethanol oxidation; IEA:InterPro. GO:0046294; P:formaldehyde catabolic process; IDA:SGD. GO:0033859; P:furaldehyde metabolic process; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |