CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018469
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FERM, RhoGEF and pleckstrin domain-containing protein 2 
Protein Synonyms/Alias
 FERM domain including RhoGEF; FIR 
Gene Name
 Farp2 
Gene Synonyms/Alias
 Kiaa0793 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
195EYLPNQEKSLEKILDubiquitination[1]
385ALTVDLPKQSVSFTDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity (PubMed:23375260 and PubMed:20702777). Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion. 
Sequence Annotation
 DOMAIN 44 324 FERM.
 DOMAIN 538 729 DH.
 DOMAIN 758 855 PH 1.
 DOMAIN 930 1027 PH 2.
 MOD_RES 375 375 Phosphoserine.
 MOD_RES 440 440 Phosphoserine (By similarity).
 MOD_RES 879 879 Phosphoserine.
 MOD_RES 884 884 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1065 AA 
Protein Sequence
MGEIEGTYRA LPTSGTRLGG QTAIGVSTLE PEQSLSPRMQ EKHMRIRVKL LDSTVELFDI 60
EPKCDGQVLL TQVWKHLNLI ECDYFGLEFK NVQSYWIWLE PMKPIIRQVR KPKNAVLRLA 120
VKFFPPDPGQ LQEEYTRYLF ALQLKRDLLE ERLTCTANTA ALLISHLLQS EIGDYDETLD 180
REHLKANEYL PNQEKSLEKI LDFHQRHTGQ TPAESDFQVL EIARKLEMYG IRFHMASDRE 240
GTKINLAVSH MGVLVFQGTT KINTFNWSKV RKLSFKRKRF LIKLHPEVHG PYQDTLEFLL 300
GSRDECKNFW KICVEYHTFF RLSDQPKPKA KAVFFSRGSS FRYSGRTQKQ LVDYVKDGGM 360
KRIPYERRHS KTRTSLHALT VDLPKQSVSF TDGLRTSASL SSANVSFYPP PSSSLSPPGL 420
PNLKDSSSSL VDPQAPVIKS TAAERSSGPS SSDGPSTQSA HLPGPPVLRP GPGFSMDSPQ 480
PSPSSLKSHL SLCPELQAAL STAEQGASPV LSPVLSGAGT ARMDNQEEQK HKHMPEDEAY 540
FIAKEILATE RTYLKDLEVI TVWFRSVLIK EEAMPAALMA LLFSNIDPVY EFHRGFLHEV 600
EQRLALWEGP SSAHLKGDHQ RIGDILLRNM RQLKEFTSYF QRHDEVLTEL EKATKHCKKL 660
EAVYKEFELQ KVCYLPLNTF LLKPVQRLVH YRLLLSRLCA HYSPGHRDYA DCHEALKAIT 720
EVTTELQQSL TRLENLQKLT ELQRDLVGVE NLIAPGREFI REGCLHKLTK KGLQQRMFFL 780
FSDMLLYTSK SVTGASHFRI RGFLPLRGML VEESENEWSV PHCFTIYAAQ KTIVVAASTR 840
LEKEKWMQDL NAAIQAAKTI GDSPPVLLGG PVYTRTPRSS DEVSLEESED GRGNRGSLEG 900
NSQHRANTTM HVCWYRNTSV SRADHSAAVE NQLSGYLLRK FKNSNGWQKL WVVFTNFCLF 960
FYKTHQDDYP LASLPLLGYS VSLPREADSI HKDYVFKLQF KSHVYFFRAE SKYTFERWMD 1020
VIKRASSSPG RPPSFTQDCS HHSPGLEAEI REKEACPSPC LDKNL 1065 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0019898; C:extrinsic to membrane; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
 GO:0031532; P:actin cytoskeleton reorganization; IMP:UniProtKB.
 GO:0007155; P:cell adhesion; IMP:UniProtKB.
 GO:0016322; P:neuron remodeling; ISO:MGI.
 GO:0030316; P:osteoclast differentiation; IMP:UniProtKB.
 GO:0071800; P:podosome assembly; IMP:UniProtKB.
 GO:0016601; P:Rac protein signal transduction; ISO:MGI.
 GO:0033623; P:regulation of integrin activation; IMP:UniProtKB.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
 GO:0071526; P:semaphorin-plexin signaling pathway; IMP:UniProtKB. 
Interpro
 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR000219; DH-domain.
 IPR000798; Ez/rad/moesin_like.
 IPR014847; FERM-adjacent.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR018980; FERM_PH-like_C.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF08736; FA
 PF09380; FERM_C
 PF00373; FERM_M
 PF09379; FERM_N
 PF00169; PH
 PF00621; RhoGEF 
SMART
 SM00295; B41
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS00741; DH_1
 PS50010; DH_2
 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3
 PS50003; PH_DOMAIN 
PRINTS
 PR00935; BAND41.
 PR00661; ERMFAMILY.