UniProt Accession

 AP1S2_HUMAN; P56377; O95326; Q9H2N6 

Genbank Protein ID

 AB015320; AF251295; BT006738; BC001117; BC071867; AF091077 

Genbank Nucleotide ID

 BAA33392.1; AAG44595.1; AAP35384.1; AAH01117.1; AAH71867.1; AAC72946.1 

Protein Name

 AP-1 complex subunit sigma-2 

Protein Synonyms/Alias

 Adapter-related protein complex 1 sigma-1B subunit; Adaptor protein complex AP-1 sigma-1B subunit; Clathrin assembly protein complex 1 sigma-1B small chain; Golgi adaptor HA1/AP1 adaptin sigma-1B subunit; Sigma 1B subunit of AP-1 clathrin; Sigma-adaptin 1B; Sigma1B-adaptin 

Gene Name

 AP1S2 

Gene Synonyms/Alias

 DC22 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
17	QGKLRLQKWYVPLSD	ubiquitination	[1, 2]
132	TSKKNVLKAIEQADL	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. 

Sequence Annotation

  

Keyword

 Coated pit; Complete proteome; Cytoplasmic vesicle; Endocytosis; Golgi apparatus; Membrane; Mental retardation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 157 AA 

Protein Sequence

Gene Ontology

 GO:0030119; C:AP-type membrane coat adaptor complex; TAS:ProtInc.
 GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
 GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0005765; C:lysosomal membrane; TAS:Reactome.
 GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
 GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.
 GO:0016032; P:viral reproduction; TAS:Reactome. 

Interpro

 IPR016635; AP_complex_ssu.
 IPR022775; AP_mu_sigma_su.
 IPR000804; Clathrin_sm-chain_CS.
 IPR011012; Longin-like_dom. 

Pfam

 PF01217; Clat_adaptor_s 

SMART

  

PROSITE

 PS00989; CLAT_ADAPTOR_S 

PRINTS