| Tag | Content |
|---|
| CPLM ID | CPLM-014893 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein PLAG1 |
Protein Synonyms/Alias | Pleiomorphic adenoma gene 1 protein |
Gene Name | PLAG1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 244 | NQELLKVKTEPVDFL | sumoylation | [1] | | 263 | CNVSVPIKDELLPVM | sumoylation | [1] |
|
Reference | [1] Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation. Van Dyck F, Delvaux EL, Van de Ven WJ, Chavez MV. J Biol Chem. 2004 Aug 20;279(34):36121-31. [ PMID: 15208321] |
Functional Description | Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. |
Sequence Annotation | ZN_FING 34 56 C2H2-type 1.
ZN_FING 62 86 C2H2-type 2.
ZN_FING 92 114 C2H2-type 3.
ZN_FING 121 143 C2H2-type 4.
ZN_FING 150 172 C2H2-type 5.
ZN_FING 185 207 C2H2-type 6.
ZN_FING 213 236 C2H2-type 7.
REGION 2 84 Interacts with KPNA2.
REGION 41 242 Decreased nuclear import with
REGION 243 500 Activates transcription; Inhibition of
REGION 243 384 Repression domain; contains 3 sumoylation
REGION 385 500 Massively activates transcription.
MOTIF 22 25 Nuclear localization signal.
CROSSLNK 244 244 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 263 263 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Acetylation; Activator; Alternative splicing; Chromosomal rearrangement; Complete proteome; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Polymorphism; Proto-oncogene; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 500 AA |
Protein Sequence | MATVIPGDLS EVRDTQKVPS GKRKRGETKP RKNFPCQLCD KAFNSVEKLK VHSYSHTGER 60
PYKCIQQDCT KAFVSKYKLQ RHMATHSPEK THKCNYCEKM FHRKDHLKNH LHTHDPNKET 120
FKCEECGKNY NTKLGFKRHL ALHAATSGDL TCKVCLQTFE STGVLLEHLK SHAGKSSGGV 180
KEKKHQCEHC DRRFYTRKDV RRHMVVHTGR KDFLCQYCAQ RFGRKDHLTR HMKKSHNQEL 240
LKVKTEPVDF LDPFTCNVSV PIKDELLPVM SLPSSELLSK PFTNTLQLNL YNTPFQSMQS 300
SGSAHQMITT LPLGMTCPID MDTVHPSHHL SFKYPFSSTS YAISIPEKEQ PLKGEIESYL 360
MELQGGVPSS SQDSQASSSS KLGLDPQIGS LDDGAGDLSL SKSSISISDP LNTPALDFSQ 420
LFNFIPLNGP PYNPLSVGSL GMSYSQEEAH SSVSQLPPQT QDLQDPANTI GLGSLHSLSA 480
AFTSSLSTST TLPRFHQAFQ 500 |
Gene Ontology | GO:0005634; C:nucleus; IBA:RefGenome. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IBA:RefGenome. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0022612; P:gland morphogenesis; IEA:Compara. GO:0006917; P:induction of apoptosis; IBA:RefGenome. GO:0035264; P:multicellular organism growth; IEA:Compara. GO:0010629; P:negative regulation of gene expression; IEA:Compara. GO:0035265; P:organ growth; IEA:Compara. GO:0010628; P:positive regulation of gene expression; IEA:Compara. GO:0060252; P:positive regulation of glial cell proliferation; IEA:Compara. GO:0060736; P:prostate gland growth; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |