CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024333
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytoskeleton-associated protein 5 
Protein Synonyms/Alias
  
Gene Name
 Ckap5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
96VVSGVVSKVFNQPKAubiquitination[1]
167ISLKPIIKVLPKLFEubiquitination[1]
438TLPKSLLKPFCAALLacetylation[2]
438TLPKSLLKPFCAALLsuccinylation[2]
754GFSELNVKAFISNVKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles (By similarity). 
Sequence Annotation
 REPEAT 159 197 HEAT 1.
 REPEAT 356 394 HEAT 2.
 REPEAT 434 472 HEAT 3.
 REPEAT 750 788 HEAT 4.
 REPEAT 855 893 HEAT 5.
 REPEAT 936 974 HEAT 6.
 REPEAT 1013 1051 HEAT 7.
 REPEAT 1284 1322 HEAT 8.
 REPEAT 1324 1357 HEAT 9.
 REPEAT 1361 1399 HEAT 10.
 MOD_RES 48 48 N6-acetyllysine (By similarity).
 MOD_RES 816 816 Phosphoserine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Mitosis; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2032 AA 
Protein Sequence
MGDDSEWLKL PVDQKCEHKL WKARLSGYEE ALKIFQKIKD EKSPEWSKYL GLIKKFVTDS 60
NAVVQLKGLE AALVYVENAH VAGKTTGEVV SGVVSKVFNQ PKAKAKELGI EICLMYVEIE 120
KGESVQEELL KGLDNKNPKI IVACIETLRK ALSEFGSKII SLKPIIKVLP KLFESRDKAV 180
RDEAKLFAIE IYRWNRDAVK HTLQNINSVQ LKELEEEWVK LPTGAPKPSR FLRSQQELEA 240
KLEQQQSAGG DAEGGGDDGD EVPQVDAYEL LDAVEILSKL PKDFYDKIEA KKWQERKEAL 300
EAVEVLVKNP KLEAGDYADL VKALKKVVGK DTNVMLVALA AKCLTGLAVG LRKKFGQYAG 360
HVVPTILEKF KEKKPQVVQA LQEAIDAIFL TTTLQNISED VLAVMDNKNP TIKQQTSLFI 420
ARSFRHCTSS TLPKSLLKPF CAALLKHIND SAPEVRDAAF EALGTALKVV GEKSVNPFLA 480
DVDKLKLDRI KECSEKVELV HGKKSGLATE KKESKPLPGR AAASGAAGDK DTKDVSGPKP 540
GPLKKTPTAK AGGPSKKGKT TAPGGSASAG TKNKKGLETK EIVEPELSIE VCEEKASAVL 600
PPTCIQLLDS SNWKERLACM EEFQKAVELM ERTEMPCQAL VKMLAKKPGW KETNFQVMQM 660
KLHIVALIAQ KGNFSKTSAQ IVLDGLVDKI GDVKCGNNAK EAMTAIAEAC MLPWTAEQVM 720
SMAFSQKNPK NQSETLNWLS NAIKEFGFSE LNVKAFISNV KTALAATNPA VRTSAITLLG 780
VMYLYVGPSL RMIFEDEKPA LLSQIDAEFQ KMQGQSPPAP TRGIAKHSTS ATDEGEDGEE 840
PGEGGNDVVD LLPRIEISDK ITSELVSKIG DKNWKIRKEG LDEVAGIINE AKFIQPNIGE 900
LPTALKGRLN DSNKILVQQT LNILQQLAVA MGANIRQHVK NLGIPVITVL GDSKNNVRAA 960
ALATVNAWAE QTGMKEWLEG EDLSEELKKE NPFLRQELLG WLAEKLPTLR STPTDLILCV 1020
PHLYSCLKDR NGDVRKKAQD ALPFFMMHLG YEKMAKATGK LKPTSKDQVL AMLEKAKANM 1080
PSKPAAPAKA MSKPMGGSAP AKTQPIPAPV EDSVSSTIEA KPDLKKAKAP GVSSKAKSVQ 1140
GKKVPSKTTL KEDDDKSGPI FIVVPNGKEQ RMRDEKGLKV LKWNFTTPRD EYIEQLKTQM 1200
STCVAKWLQD EMFHSDFQHH NKALAVMVDH LESEKDGVIS CLDLILKWLT LRFFDTNTSV 1260
LMKALEYLKL LFTLLSEEEY HLTENEASSF IPYLILKVGE PKDVIRKDVR AILNRMCLVY 1320
PASKMFPFIM EGTKSKNSKQ RAECLEELGC LIESYGMNVC QPTPGKALKE IAIHIGDRDN 1380
AVRNAALNTI VTVYNVHGDQ VFKLIGNLSE KDMSMLEERI KRSAKRPSAA PVKQAEEKPQ 1440
RTQNINSNAN MLRKGPAEDM SSKLNQARSL SGHPEAAQMV RREFQLDLDE IENDNGTVRC 1500
EMPELVQHKL DDIFEPVLIP EPKIRAVSPH FDDMHSNTAS TINFIISQVA SGDINTSIQA 1560
LTQIDEVLRQ EDKAEAMSGH IDQFLIATFM QLRLIYSTHM ADEKLDKDEI IKLYSCIIGN 1620
MISLFQIESL AREASTGVLK DLMHGLITLM LDSRIEDLEE GQQVIRSVNL LVVKVLEKSD 1680
QTNILSALLV LLQDSLLATA SSPKFSELVM KCLWRMVRLL PDTINSINLD RILLDIHIFM 1740
KVFPKEKLKQ CKSEFPIRTL KTLLHTLCKL KGPKILDHLT MIDNKNESEL EAHLCRMMKH 1800
SMDQTGSKSD KETEKGASRI DEKSSKAKVN DFLAEIFKKI GSKENTKEGL AELYEYKKKY 1860
SDTDIEPFLK NSSQFFQSYV ERGLRVIEME RESKGRIPTS TGISPQMEVT CVPTPTSTVS 1920
SLGNTNGEEV GPSVYLERLK ILRQRCGLDN TKQDDRPPLT SLLSKPAIPP VASSTDMLHS 1980
KLSQLRESRE QHQHSDLDSN QTHSAGTMTS SSSTTNIDDL KKRLERIKSS RK 2032 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; ISO:MGI.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0050658; P:RNA transport; ISS:UniProtKB. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR024395; CLASP_N_dom.
 IPR021133; HEAT_type_2. 
Pfam
 PF12348; CLASP_N 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS