| Tag | Content |
|---|
| CPLM ID | CPLM-023232 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
Protein Synonyms/Alias | ADAM-TS 5; ADAM-TS5; ADAMTS-5; A disintegrin and metalloproteinase with thrombospondin motifs 11; ADAM-TS 11; ADAMTS-11; ADMP-2; Aggrecanase-2 |
Gene Name | ADAMTS5 |
Gene Synonyms/Alias | ADAMTS11; ADMP2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 720 | GSKLQYDKCGVCGGD | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period. |
Sequence Annotation | DOMAIN 267 476 Peptidase M12B.
DOMAIN 485 566 Disintegrin.
DOMAIN 567 622 TSP type-1 1.
DOMAIN 875 929 TSP type-1 2.
REGION 732 874 Spacer.
MOTIF 207 214 Cysteine switch (By similarity).
ACT_SITE 411 411 By similarity.
METAL 209 209 Zinc; in inhibited form (By similarity).
METAL 410 410 Zinc; catalytic (By similarity).
METAL 414 414 Zinc; catalytic (By similarity).
METAL 420 420 Zinc; catalytic (By similarity).
CARBOHYD 498 498 N-linked (GlcNAc...) (Potential).
CARBOHYD 570 570 C-linked (Man).
CARBOHYD 573 573 C-linked (Man).
CARBOHYD 582 582 O-linked (Fuc...).
CARBOHYD 728 728 N-linked (GlcNAc...) (Potential).
CARBOHYD 802 802 N-linked (GlcNAc...) (Potential).
CARBOHYD 807 807 N-linked (GlcNAc...) (Potential).
DISULFID 388 471 By similarity.
DISULFID 426 455 By similarity.
DISULFID 579 616 By similarity.
DISULFID 583 621 By similarity.
DISULFID 594 606 By similarity. |
Keyword | 3D-structure; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein; Hydrolase; Metal-binding; Metalloprotease; Polymorphism; Protease; Reference proteome; Repeat; Secreted; Signal; Zinc; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 930 AA |
Protein Sequence | MLLGWASLLL CAFRLPLAAV GPAATPAQDK AGQPPTAAAA AQPRRRQGEE VQERAEPPGH 60
PHPLAQRRRS KGLVQNIDQL YSGGGKVGYL VYAGGRRFLL DLERDGSVGI AGFVPAGGGT 120
SAPWRHRSHC FYRGTVDGSP RSLAVFDLCG GLDGFFAVKH ARYTLKPLLR GPWAEEEKGR 180
VYGDGSARIL HVYTREGFSF EALPPRASCE TPASTPEAHE HAPAHSNPSG RAALASQLLD 240
QSALSPAGGS GPQTWWRRRR RSISRARQVE LLLVADASMA RLYGRGLQHY LLTLASIANR 300
LYSHASIENH IRLAVVKVVV LGDKDKSLEV SKNAATTLKN FCKWQHQHNQ LGDDHEEHYD 360
AAILFTREDL CGHHSCDTLG MADVGTICSP ERSCAVIEDD GLHAAFTVAH EIGHLLGLSH 420
DDSKFCEETF GSTEDKRLMS SILTSIDASK PWSKCTSATI TEFLDDGHGN CLLDLPRKQI 480
LGPEELPGQT YDATQQCNLT FGPEYSVCPG MDVCARLWCA VVRQGQMVCL TKKLPAVEGT 540
PCGKGRICLQ GKCVDKTKKK YYSTSSHGNW GSWGSWGQCS RSCGGGVQFA YRHCNNPAPR 600
NNGRYCTGKR AIYRSCSLMP CPPNGKSFRH EQCEAKNGYQ SDAKGVKTFV EWVPKYAGVL 660
PADVCKLTCR AKGTGYYVVF SPKVTDGTEC RLYSNSVCVR GKCVRTGCDG IIGSKLQYDK 720
CGVCGGDNSS CTKIVGTFNK KSKGYTDVVR IPEGATHIKV RQFKAKDQTR FTAYLALKKK 780
NGEYLINGKY MISTSETIID INGTVMNYSG WSHRDDFLHG MGYSATKEIL IVQILATDPT 840
KPLDVRYSFF VPKKSTPKVN SVTSHGSNKV GSHTSQPQWV TGPWLACSRT CDTGWHTRTV 900
QCQDGNRKLA KGCPLSQRPS AFKQCLLKKC 930 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |